Highlighting the interaction between immunomodulatory properties of mesenchymal stem cells and signaling pathways contribute to Graft Versus Host Disease management |
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| Institution: | 1. Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Department of Anesthesiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Department of General Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;6. Department of Immunology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran;1. Department of Gastroenterology, The 940th Hospital of Joint Service Logistics Support Force of Chinese People''s Liberation Army, Lanzhou 730050, Gansu, China;2. The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China;1. Joint Trauma Center, PLA 371 Center Hospital, Department of Orthopedics, 371 Hospital, Xinxiang Medical University, Xinxiang 453003, PR China;2. Department of Digestive System, PLA 371 Center Hospital, Xinxiang Medical University, Xinxiang 453003, PR China;1. Department of Surgical Nursing, Faculty of Health Sciences, Malatya Turgut Ozal University, Malatya, Turkey;2. Department of Surgical Nursing, Inonu University, Faculty of Nursing, Campus 44280, Malatya, Turkey;1. Department of Bone and Joint Surgery, Wendeng Orthopaedic Hospital of Shandong Province, Shandong, China;2. Department of Orthopaedics, Qingdao Municipal Hospital, Shandong, China;3. Department of Spine and Spinal Cord, Wendeng Orthopaedic Hospital of Shandong Province, Shandong, China;4. Department of Hand and Microsurgery, Wendeng Orthopaedic Hospital of Shandong Province, Shandong, China;5. Department of Limb Trauma, Wendeng Orthopaedic Hospital of Shandong Province, Shandong, China;1. Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India;2. Department of Urology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India;3. Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India |
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| Abstract: | BackgroundAllogeneic hematopoietic stem cell transplantation (Allo-HSCT) has been increasingly used as a therapeutic approach for hematological malignancies. Several potential strategies have been developed for treating or preventing allo-HSCT complications, specifically graft-versus-host disease (GVHD). GVHD could significantly affect the morbidity and mortality of patients after allo-HSCT. Curative treatment and prophylaxis regimens for GVHD could reduce GVHD incidence and improve survival rate. Among these therapeutic strategies, mesenchymal stem cell (MSCs) mediated immunomodulation has been explored widely in clinical trials. MSCs immunomodulation ability in GVHD correlates with the interactions of MSCs with innate and adaptive immune cells. However, signaling pathways responsible for MSCs' impact on GVHD regulation, like JAK/STAT, NOTCH, MAPK/ERK, and NFκβ signaling pathways, have not been clearly described yet. This review aims to illuminate the effect of MSCs-mediated immunomodulation in GVHD management after allo-HSCT representing the role of MSCs therapy on signaling pathways in GVHD.ConclusionMSCs could potentially modulate immune responses, prevent GVHD, and improve survival after allo-HSCT. Previous studies have investigated different signaling pathways' contributions to MSCs immunoregulatory ability. Accordingly, targeting signaling pathways components involved in MSCs related GVHD regulation is proven to be beneficial. |
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