Forensic features and genetic structure revealed by 47 individual identification InDels in the Shaanxi Han population |
| |
| Affiliation: | 1. Sezione di Medicina Legale e delle Assicurazioni–Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milano, Italy;2. Surgical Pathology Unit, Ospedale San Gerardo, Università degli Studi di Milano-Bicocca, Monza, Italy;3. Department of Clinical Electrophysiology and Arrhythmia, Centro Cardiologico Monzino, IRCSS, Milano, Italy;1. Department of Forensic Medicine, Graduate School of Medicine, Hokkaido University, N15 W 7 Kita-ku, Sapporo, Hokkaido 060-8638, Japan;2. Center for Cause of Death Investigation, Graduate School of Medicine, Hokkaido University, Hokkaido 060-8638, Japan;3. Center for Medical Education and International Relations, Graduate School of Medicine, Hokkaido University, Hokkaido 060-8638, Japan;1. Tokat State Hospital, Tokat, Turkey;2. Department of Forensic Medicine, Medical Faculty Hospital of Selcuk University, Konya, Turkey;3. Ankara City Hospital of Health Sciences University, Ankara, Turkey;4. Department of Forensic Medicine, Medical Faculty of Van Yuzuncu Yil University, Van, Turkey;5. Biostatistics Department, Medical School of Van Yuzuncu Yil University, Van, Turkey;6. Department of Radiology, Antalya Training and Research Hospital of Health Sciences University, Antalya, Turkey;7. Department of Forensic Medicine, Medical Faculty of Bahçeşehir University, Istanbul, Turkey;1. CHU Lille, Unité Fonctionnelle de Toxicologie, F-59037 Lille, France;2. Univ. Lille, URL 4483 – IMPECS – IMPact de l’Environnement Chimique sur la Santé humaine, F-59000 Lille, France;1. Department of Pediatric Dentistry, Virginia Commonwealth University, 520 North 12th Street, Richmond, VA 23298, USA;2. Department of Developmental Dentistry, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA;3. Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Guy’s Hospital, Tower Wing, Great Maze Pond, London Bridge, London SE1 9RT, UK |
| |
| Abstract: | Insertion/deletion (InDel) polymorphism genetic marker is a powerful and prospective tool for human identification and population genetic studies. Considering that the genetic polymorphisms and ethnic background of the Shaanxi Han population have not been fully explored to this day, herein, the novel developed AGCU InDel 50 kit which included 47 autosomal InDels was applied in the 556 unrelated healthy Han individuals from Shaanxi province for the first time. There were no significant deviations from Hardy–Weinberg equilibrium and linkage equilibrium at the 47 InDels after Bonferroni correction. In the Shaanxi Han population, the values of combined discrimination power and cumulative exclusion probability for the 47 InDels were 0.999999999999999999891 and 0.99966, respectively. Furthermore, the interpopulation comparisons and population genetic structure analyses based on the 47 InDels were performed among the Shaanxi Han population and 43 reference populations, and the results showed that the Shaanxi Han population exhibited similar genetic structure and closer genetic affinities with the East Asian populations. |
| |
| Keywords: | Insertion/deletion polymorphism Population genetics Shaanxi Han population |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
