Intra-articular ozone slows down the process of degeneration of articular cartilage in the knees of rats with osteoarthritis |
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| Affiliation: | 1. Graduate Program in Human Aging, University of Passo Fundo, Passo Fundo, Rio Grande do Sul, Brazil;2. Clinical Hospital of Passo Fundo, Passo Fundo, Rio Grande do Sul, Brazil;3. Graduate Program in Bioexperimentation, University of Passo Fundo, Passo Fundo, Rio Grande do Sul, Brazil;4. College of Pharmacy, University of Passo Fundo, Passo Fundo, Rio Grande do Sul, Brazil;5. College of Physical Education, University of Passo Fundo, Passo Fundo, Rio Grande do Sul, Brazil;6. Graduate Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil;7. School of Veterinary Medicine, IMED, Passo Fundo, Rio Grande do Sul, Brazil;1. Department of Orthopaedic and Trauma Surgery, “Città di Parma” Clinic, Parma, Italy;2. Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy;1. Department of Oral Biology, Faculty of Dentistry, Cairo University, Cairo, Egypt;2. Stem Cells and Tissue Engineering Unit, Faculty of Dentistry, Cairo University, Cairo, Egypt;3. Department of Oral Biology, Faculty of Dentistry, Suez University, Suez, Egypt;4. Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt;1. Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, China;2. Department of Orthopaedics, Changshu Hospital Affiliated to Soochow University, First People''s Hospital of Changshu City, Changshu, Jiangsu, China |
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| Abstract: | BackgroundOsteoarthritis (OA) is a joint disease of multifactorial etiology, affecting mainly the knees. We aimed to evaluate the effects of two different doses of gaseous ozone intra-articularly on the knee cartilage morphology of rats with osteoarthritis (OA).MethodsThe articular lesion was induced by sodium monoiodoacetate (MIA). 40 Wistar rats were divided into 4 groups: G1 control (without lesion and without treatment), G2 articular lesion (AL) (only lesion MIA-induced), G3 AL + treatment with 5 μg/mL of ozone intra-articular, and G4 AL + treatment with 10 μg/mL of ozone intra-articular. The experiment was carried out for 60 days.ResultsBoth doses of ozone intra-articular demonstrated less reduction in joint space (G3 and G4) compared to the G2, formation of osteophytes, but without subchondral sclerosis. Ozone decreased the volumetric density of the articular lesion (VV(AL)) of tibial. The treatments recovered VV(AL) of the femur similar to G1. Ozone lower dose (G3) showed lower tibia and femur macroscopic scores.ConclusionIntra-articular gaseous ozone can delay the degeneration of articular cartilage and can represents an integrative therapy in the OA treatment of knee after 60 days of treatment. For the first time the role of ozone in articular cartilage degeneration was evaluated helping to understand this therapy. |
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| Keywords: | Articulation Cartilage Degeneration Osteoarthrosis Ozone |
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