提高低压低氧环境下红细胞氧亲和力的策略及潜在药物

目的 归纳和总结目前研究中能够在低压低氧环境下提高红细胞氧亲和力的策略及潜在的药物。方法 通过查阅CNKI数据库、Web of Science数据库及Pubmed数据库中有关低压低氧环境与红细胞氧亲和力关系的文献，对其进行筛选、提取和归纳总结。结果 低压低氧环境下，机体摄氧能力、氧气利用效率下降，导致机体处于缺氧状态。提高红细胞氧亲和力可帮助机体适应与习服低压低氧环境，且较多提高方式已在其他疾病中得到应用。结论 通过提高低压低氧环境下红细胞氧亲和力来提高氧气的利用率是目前预防高原低压低氧环境对人体损伤研究的起点与重点。

Strategies and Potential Drugs to Improve Erythrocyte Oxygen Affinity in Hypobaric and Hypoxic Environment

OBJECTIVE To summarize the strategies and potential drugs that can improve the oxygen affinity of red blood cells in the hypobaric and hypoxic environment in the current research. METHODS The retrieved literatures were screened, extracted and summarized by referring to the literature on the relationship between hypobaric hypoxic environment and erythrocyte oxygen affinity in CNKI database, Web of Science database and Pubmed database. RESULTS Under the hypobaric and hypoxic environment, the body’s oxygen uptake capacity and oxygen utilization efficiency decreased, resulting in the body being in a state of hypoxia. Improving the oxygen affinity of red blood cells could help the body adapt to and get used to the hypobaric and hypoxic environment, and many improvement methods had been applied in other diseases. CONCLUSION Improving the oxygen utilization rate of red blood cells by increasing the oxygen affinity of erythrocytes under hypobaric and hypoxia environment is the starting point and focus of the current research on preventing the damage of high altitude hypobaric and hypoxic environment to the human body.