Correlation between CYP3A5 gene polymorphism and BK virus infection in kidney transplant recipients |
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| Affiliation: | 1. Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan;2. Department of Hematology, Sasebo City General Hospital, Sasebo, Japan;3. Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan;4. Department of Hematology, National Hospital Organization Nagasaki Medical Center, Omura, Japan;5. Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan;6. Department of Hematology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan;1. Neurological Surgery Department, University of São Paulo, School of Medicine, São Paulo, Brazil;2. Organ Procurement Organization, Hospital das Clínicas, University of São Paulo, School of Medicine, São Paulo, Brazil;3. Gastroenterology Department, University of São Paulo, School of Medicine, São Paulo, Brazil;4. Medical Science Department, Nove de Julho University, São Paulo, Brazil;5. Cardiopneumology Department, University of São Paulo, School of Medicine, São Paulo, Brazil;6. School of Nursing of the University of São Paulo, São Paulo, Brazil;1. Division of Hematology with BMT, A.O.U. “Policlinico-San Marco”, Via S. Sofia 78, 95123 Catania, Italy;2. Onco-Hematology and BMT Unit, “Mediterranean Institute of Oncology”, Viagrande, Italy;3. Division of Nephrology, A.O.U. Policlinico “G. Rodolico-San Marco”, Catania, Italy;1. Department of Oncology, The First Hospital, Jilin University, Changchun 130021, China;2. Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital, Jilin University; Changchun, 130061, China;3. National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun 130061, China;4. Department of Hematology, The First Hospital, Jilin University, Changchun 130021, China;1. Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA;2. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA;3. Division of Plastic Surgery and Hand Surgery, University Hospital Zurich, Zurich, ZH, Switzerland;4. th;5. Department of Surgery, Uniformed Service University of the Health Sciences, Bethesda, MD, USA;6. Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA;7. Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC, USA;8. Division of Plastic Surgery, Department of Surgery, University of Colorado, Denver, CO, USA;9. Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA;1. Department of Renal Surgery and Transplantation, Jichi Medical University Hospital, Tochigi, Japan;2. Department of Orthopaedics, Teikyo University School of Medicine, Tokyo, Japan;3. Oku medical clinic, Osaka, Japan;4. Scientific Research WorkS Peer Support Group (SRWS-PSG), Osaka, Japan |
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| Abstract: | BackgroundCytochrome P450 3A5 (CYP3A5) includes two active genotypes, namely CYP3A5*1/*1 or *1/*3 with the fast metabolic activity and CYP3A5*3/*3 with slow metabolic. We retrospectively analyzed the correlation between CYP3A5 gene polymorphism and the susceptibility to the BK virus (BKV) infection in renal transplant recipients.MethodsAccording to the inclusion/ exclusion criteria, we selected 134 recipients who received kidney transplantation at the Renmin Hospital of Wuhan University from January 2019 to December 2019. Based on the pre-operative CYP3A5 sequencing results, 134 recipients were divided into two groups: those expressing the fast metabolic CYP3A5*1/*1 or *1/*3 genotype; and, those expressing slow metabolic CYP3A5*3/*3 genotype. These two recipient groups were then analyzed for the BKV infection rate with different metabolic types to establish the potential relationship between CYP3A5 gene polymorphism and BKV infection.ResultsThe overall incidence of BKV viruria was 37.3%, whereas BKV viremia was 4.5% among all 134 recipients. The fast metabolism group had 9.1% incidence of BKV viremia and 49.1% incidence of BKV viruria. In contrast, the slow metabolism group had only 1.3%incidence of BKV viremia (P = 0.031) with only 29.1% BKV viruria (P = 0.011). The incidence of low levels of urinary BKV in the fast metabolism group was higher than that in the slow metabolism group (P = 0.005), while no significant statistical difference in the incidence of high levels of urinary BKV and high and low levels of blood BKV.ConclusionAfter kidney transplantation, CYP3A5 gene polymorphism of recipients present a certain relationship with the occurrence of BKV infection, which may be of value for the prediction and prevention of BKV infection. |
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