Transcatheter arterial embolization of abnormal neovessels in a swine model of knee arthritis |
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| Affiliation: | 1. Department of Radiology, Wakayama Medical University, Wakayama, Japan;2. Department of Radiology, IGT Clinic, Izumisano, Osaka, Japan;3. Musculoskeletal Intervention Center, Okuno Clinic, Tsuzuki-ku, Yokohama, Kanagawa, Japan;4. Medical Corporation Yuyukai, OKUNO CLINIC., Minato-ku, Tokyo, Japan;1. Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea;2. Department of Orthopedic Surgery, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea;3. Department of Radiology, Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea;1. Vascular and Interventional Radiology and the University Hospital of León, Calle Altos de Nava, SN 24080, León, Spain;2. Institute of Biomedicine (IBIOMED), University of León, León, Spain;3. Radiology Department, Clínica Universidad de Navarra, Madrid, Spain;4. Physical Chemistry Area, Faculty of Biology and Environmental Sciences, University of León, León, Spain;5. Radiology Department, University Hospital of León, Calle Altos de Nava, SN 24080, León, Spain;1. Department of Radiology, Wakayama Medical University, Wakayama, Japan;2. Department of Human Pathology, Wakayama Medical University, Wakayama, Japan;1. Department of Vascular and Interventional Radiology, Vascular Institute of Virginia, 14085 Crown Court, Woodbridge, VA, 22913;2. Department of Radiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina;3. Department of Orthopedics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina;1. Department of Radiology, Centre hospitalier de l''Université de Montréal, Research Centre (CRCHUM), 900 rue Saint-Denis, Montreal H2X 0A9, Canada;2. Clinical Image Processing Laboratory, Centre hospitalier de l''Université de Montréal, Research Centre (CRCHUM), 900 rue Saint-Denis, Montreal H2X 0A9, Canada;3. Osteoarthritis Research Unit, Centre hospitalier de l''Université de Montréal, Research Centre (CRCHUM), 900 rue Saint-Denis, Montreal H2X 0A9, Canada;4. Biostatistics/Methodology Core Facility, Centre hospitalier de l''Université de Montréal, Research Centre (CRCHUM), 900 rue Saint-Denis, Montreal H2X 0A9, Canada;5. Animal Facility, Centre hospitalier de l''Université de Montréal, Research Centre (CRCHUM), 900 rue Saint-Denis, Montreal H2X 0A9, Canada;6. Department of Diagnostic and Interventional Radiology, Hôpital Maisonneuve-Rosemont, Montreal, Canada;7. Department of Pathology and Cellular Biology, Hôpital Maisonneuve-Rosemont, Montreal, Canada;8. Okuno Clinic, 7-8-4, Tokyo, Japan;9. Department of Radiology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Denmark;10. Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, Montreal, Canada;11. Vascular and Oncological Interventional Radiology Department, Hôpital Européen George Pompidou, Assistance Publique Hôpitaux de Paris; Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France |
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| Abstract: | BackgroundIn recent years, transcatheter arterial embolization (TAE) using imipenem/cilastatin (IPM/CS) has attracted attention as a treatment for relieving osteoarthritis (OA) pain. However, IPM/CS is not approved by Japanese medical insurance for use as an embolic material. Therefore, it is necessary to develop new embolic materials for TAE to relieve OA pain. The purpose of this study was to develop a swine model of knee arthritis and embolize abnormal neovessels (ANs) using two different embolic materials. We compared the embolic effects and tissue damage in knees.MethodsKnee arthritis was induced by intra-articular injection of papain into 12 knees in six female swine. The swine were divided into two groups of three swine each (six knees per group) for embolization of ANs in the knees with either IPM/CS or soluble gelatin sponge particles (SGSs). Three days after embolization, we compared the embolic effects using angiography and the tissue damage histopathologically.ResultsANs were observed in all 12 knees at 42 days after papain injection. The ANs disappeared and the patent arteries were recanalized 3 days after TAE in all 12 knees. Histopathological evaluation revealed synovitis changes, such as synovial thickening and inflammatory cell infiltration, in all 12 knees. There was no evidence of skin or muscle necrosis in either group. The appearance of ANs, recanalization of the parent arteries, and histopathological outcomes were not significantly different between the two groups.ConclusionSGSs were as safe as IPM/CS for TAE of ANs in this swine model of knee arthritis. |
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| Keywords: | Osteoarthritis Knee Transcatheter arterial embolization Abnormal neovessels Imipenem/cilastatin Soluble gelatin sponge OA" },{" #name" :" keyword" ," $" :{" id" :" pc_ot4pmI27XC" }," $$" :[{" #name" :" text" ," _" :" osteoarthritis TAE" },{" #name" :" keyword" ," $" :{" id" :" pc_VL4HqsbVpQ" }," $$" :[{" #name" :" text" ," _" :" transcatheter arterial embolization IPM/CS" },{" #name" :" keyword" ," $" :{" id" :" pc_k3KkLTcrlR" }," $$" :[{" #name" :" text" ," _" :" imipenem/cilastatin AN" },{" #name" :" keyword" ," $" :{" id" :" pc_kiSTnLpUj5" }," $$" :[{" #name" :" text" ," _" :" abnormal neovessel SGS" },{" #name" :" keyword" ," $" :{" id" :" pc_q5kH5U6c1B" }," $$" :[{" #name" :" text" ," _" :" soluble gelatin sponge particle ACL" },{" #name" :" keyword" ," $" :{" id" :" pc_cytCLU7j72" }," $$" :[{" #name" :" text" ," _" :" anterior cruciate ligament GAE" },{" #name" :" keyword" ," $" :{" id" :" pc_GvQDv6uMjH" }," $$" :[{" #name" :" text" ," _" :" genicular artery embolization |
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