Drug transporters are implicated in the diffusion of tacrolimus into the T lymphocyte in kidney and liver transplant recipients: Genetic,mRNA, protein expression,and functionality |
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Affiliation: | 1. Irset (Institut de Recherche en Santé, Environnement et Travail)—UMR S 1085, EHESP, Inserm, CHU Rennes, Université Rennes 1, F-35000, Rennes, France;2. INSERM, Centre d’Investigation Clinique 1414, F-35000, Rennes, France;3. Service de pharmacologie biologique, Centre Hospitalier Universitaire de Rennes, Université de Rennes 1, Rennes, France;4. Service de chirurgie hépato-biliaire et digestive, Centre Hospitalier Universitaire de Rennes, Université de Rennes 1, Rennes, France;5. Service de néphrologie, Centre Hospitalier Universitaire de Rennes, Université de Rennes 1, Rennes, France;6. Laboratoire d''hématologie, Centre Hospitalier Universitaire de Rennes, Université de Rennes 1, Rennes, France;7. Laboratoire de génétique moléculaire et génomique médicale, Centre Hospitalier Universitaire de Rennes, Université de Rennes 1, Rennes, France;8. Université de Rennes, Établissement Français du Sang (EFS) de Bretagne, Inserm, MICMAC-UMR_S1236, Rennes, France;9. Université Rennes, CNRS, IGDR, UMR, 6290, Rennes, France;1. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan;2. Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan;3. Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan;4. Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan;5. Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan;1. Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai, 980-8578, Japan;2. Division of Risk Assessment, National Institute of Health Sciences, Tonomachi 3-25-26, Kawasaki-ku, Kawasaki, 210-9501, Japan;3. Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526 Japan;4. Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co, Ltd, 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-0192, Japan;1. Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, PR China;2. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, Institute for Liver Diseases of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China;3. The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine, Hefei, 230032, PR China;4. Center for Scientific Research of Anhui Medical University, Hefei, 230032, PR China;5. Hefei Kaifan Analytical Technology Co., Ltd., Hefei, 230051, PR China;1. Laboratory of Membrane Transport for Biopharmaceutics, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Japan;2. Laboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Japan;1. Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan;2. Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Kainan, Japan;3. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan;1. Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;2. Unit of Excellence on Pharmacogenomic Pharmacokinetic and Pharmacotherapeutic Researches (UPPER), School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand;3. Pharmacy Unit, Udon Thani Hospital, Udon Thani, Thailand;4. Division of Dermatology, Department of Internal Medicine, Khon Kaen Hospital, Khon Kaen, Thailand;5. Pharmacy Department, Khon Kaen Hospital, Khon Kaen, Thailand;6. Pharmacy Unit, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand |
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