基于加权TOPSIS法的儿童患者注射用炎琥宁的药物利用评价

目的 建立基于加权TOPSIS法的儿童患者注射用炎琥宁的药物利用评价，促进其临床合理应用。方法 以注射用炎琥宁药品说明书为依据，参考注射用炎琥宁临床使用相关文献，建立基于加权TOPSIS法的儿童患者注射用炎琥宁的药物利用评价标准，依据建立的评价标准回顾性评价徐州医科大学附属徐州儿童医院2022年1月-2022年12月注射用炎琥宁使用情况。结果 360份评价病历加权TOPSIS法评价显示，与最优方案最高接近度为84.06%，最低接近度为40.03%。相对接近度<60%的有165例（45.83%），60%≤相对接近度<70%的有159例（44.17%），70%≤相对接近度<80%的有32例（8.89%），80%≤相对接近度<90%的有4例（1.11%），没有相对接近度≥ 90%的病历。结论 基于加权TOPSIS法的儿童患者注射用炎琥宁药物利用评价标准可以用于该药在儿童患者的用药合理性评价，评价结果显示徐州医科大学附属徐州儿童医院注射用炎琥宁临床应用中存在不合理用药情况，需进一步加强管控。

Drug utilization review of Potassium Sodium Dehydroandroandrographolide Succinate for injection based upon weighted TOPSIS method in children

Objective To establish weighted TOPSIS method for evaluating Potassium Sodium Dehydroandroandrographolide Succinate for injection and promote its rational clinical application. Methods The evaluation criteria of Potassium Sodium Dehydroandroandrographolide Succinate for injection in children was established with reference to its package insert and the relevant guidelines. The use of Potassium Sodium Dehydroandroandrographolide Succinate for injection in in Xuzhou Children''s Hospital, Xuzhou Medical University from January 2022 to December 2022 were retrospectively evaluated according to the established evaluation criteria. Results The evaluation of 360 medical records by weighted TOPSIS method showed that the highest approximation to the optimal scheme was 84.06%, and the lowest approximation was 40.03%. There were 165 cases (45.83%) in relative proximity < 60%, 159 cases (44.17%) in relative proximity between 60% to 70%, 32 cases (8.89%) in relative proximity between 70% to 80%, 4 cases (1.11%) in relative proximity between 80% to 90%, and no case in relative proximity > 90%. Conclusion The evaluation criteria of Potassium Sodium Dehydroandroandrographolide Succinate for injection in children based on the weighted TOPSIS method can be used to evaluate the rationality of Potassium Sodium Dehydroandroandrographolide Succinate for injection in children. The evaluation results show that there are still unreasonable use of Potassium Sodium Dehydroandroandrographolide Succinate for injection in Xuzhou Children''s Hospital, Xuzhou Medical University, which needs to be further strengthened.