Serum follistatin level as a prognostic marker in Haploidentical stem cell transplantation |
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| Affiliation: | 1. Department of Neurosurgery, Dongguan People''s Hospital (Affiliated Dongguan Hospital, Southern Medical University), Dongguan, Guangdong Province, China;2. Department of Neurosurgery, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical University, Guangzhou, China;3. Department of Cerebrovascular Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou 510360, Guangdong, China;1. Department of Gastroenterology, The 940th Hospital of Joint Service Logistics Support Force of Chinese People''s Liberation Army, Lanzhou 730050, Gansu, China;2. The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China;1. Department of Nephrology, Jiangxi Provincial People''s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, China;2. Department II of Respiratory and Critical Care, Jiangxi Provincial People''s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, China;1. Department of Cardiovascular Surgery, The First School of Clinical Medicine Lanzhou University, Lanzhou 730000, China;2. Department of Anesthesiology, The People''s Hospital of Hui County, Long nan 742300, China;1. Key Laboratory of Functional and Clinical Translational Medicine, Fujian Province University, Xiamen Medical College, Xiamen, Fujian 361023,China;2. Department of Basic Medicine, Xiamen Medical College, Xiamen, Fujian 361023, China;3. The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian 361023, China;4. Medical College of Xiamen University, Xiamen, Fujian 361100, China |
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| Abstract: | BackgroundThe treatment of hematological diseases with Haploidentical transplantation has made significant progress. Follistatin is an angiogenic factor that is elevated in the circulation after allogeneic Hematopoietic Cell Transplantation (HCT). Elevated follistatin levels have been linked to poor survival after graft versus host disease (GVHD).ObjectivePre- and post-transplant Follistatin levels were measured in patients subjected to Haploidentical HSCT and correlated with transplant outcomes.Patients and methodsThis study included 45 patients who underwent allogeneic stem cell transplants from Haploidentical donors.ResultsThe mean Follistatin level before stem cells infusion (88.81 ± 49.11 ng/ml) and at day 28 post-transplant (78.61 ± 45.50 ng/ml). The mean follistatin level was higher among the patients who had acute severe GVHD grade 3–4 pre-transplant at day zero and day 28 without statistical significance.The incidence of veno-occlusive disease was higher in patients with elevated serum follistatin levels on day 0 (108.58 ± 64.12 Vs 82.16 ± 46.05 ng/ml. p value = 0.134) and day 28 (112 ± 49.36 vs 66.06 ± 38.96 ng/ml) with statistically significance at day 28 post-transplant (p value = 0.011).After 180 days of follow-up, patients with high serum follistatin (i.e. >60 ng/ml) on day 28 post-transplant had lower OS, (P = 0.381).ConclusionIn the setting of Haploidentical HSCT, higher follistatin levels post-transplant are associated with severe acute GVHD and inferior overall survival. |
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