银杏酮酯滴丸联合贝尼地平治疗冠心病心绞痛的临床研究

目的 探讨银杏酮酯滴丸联合盐酸贝尼地平片治疗冠心病心绞痛的临床疗效。方法 选取2020年2月-2023年1月武警特色医学中心收治的68例冠心病心绞痛患者，根据计算机随机排列法将所有患者分为对照组和治疗组，每组各34例。对照组患者口服盐酸贝尼地平片，2片/次，1次/d。治疗组在对照组基础上口服银杏酮酯滴丸，8丸/次，3次/d。两组患者连续治疗14 d。观察两组的临床疗效，比较两组的心绞痛发作频率、每次发作持续时间、心绞痛程度、心功能指标以及血清中CD105、金属基质蛋白酶-3（MMP-3）、同型半胱氨酸（Hcy）、脂蛋白磷脂酶（Lp-PLA2）、肌钙蛋白T （cTnT）水平。结果 治疗后，治疗组的总有效率94.12%比对照组的总有效率76.47%高（P<0.05）。治疗后，两组的心绞痛发作频率、每次发作持续时间明显低于治疗前（P<0.05），且治疗组心绞痛发作频率、每次发作持续时间较对照组更低（P<0.05）。治疗后，两组的视觉模拟评分法（VAS）评分显著降低（P<0.05），治疗组VAS评分较对照组降低更明显（P<0.05）。治疗后，两组的心排血量（CO）、左心室射血分数（LVEF）高于治疗前（P<0.05），且治疗组CO、LVEF较对照组更高（P<0.05）。治疗后，两组的CD105水平高于治疗前，MMP-3、Hcy水平低于治疗前（P<0.05）；治疗后，治疗组的CD105水平高于对照组，MMP-3、Hcy水平低于对照组（P<0.05）。治疗后，两组的脂蛋白磷脂酶（Lp-PLA2）、肌钙蛋白T （cTnT）水平低于治疗前（P<0.05）；治疗后治疗组的Lp-PLA2、cTNT水平低于对照组（P<0.05）。结论 银杏酮酯滴丸联合盐酸贝尼地平片治疗冠心病心绞痛的疗效确切，能显著提高疗效，减轻心绞痛症状和心肌损伤。

Clinical study on Ginkgo Ketone Ester Dropping Pills combined with benidipine in treatment of angina pectoris of coronary heart disease

Objective To investigate the clinical effect of Ginkgo Ketone Ester Dropping Pills combined with Benidipine Hydrochloride Tablets e in treatment of angina pectoris of coronary heart disease. Methods Patients (68 cases) with angina pectoris of coronary heart disease in Special Medical Center of Armed Police from February 2020 to January 2023 were divided into control and treatment groups according to the computer random arrangement method, and each group had 34 cases. Patients in the control group were po administered with Benidipine Hydrochloride Tablets, 2 tablets/time, once daily. Patients in the treatment group were po administered with Ginkgo Ketone Ester Dropping Pills on the basis of the control group, 8 pills/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the frequency and duration of angina attacks, VAS scores, CO, LVEF, the levels of CD105, MMP-3, Hcy, Lp-PLA2, and cTnT in two groups were compared. Results After treatment, the total effective rate (94.12%) of the treatment group was higher than 76.47% in the control group (P< 0.05). After treatment, the frequency and duration of angina attacks in two groups were significantly lower than before treatment (P < 0.05), and the frequency and duration of angina attacks in the treatment group were lower than those in the control group (P < 0.05). After treatment, VAS scores of two groups were significantly decreased (P < 0.05), and VAS score of the treatment group were decreased more significantly than that of the control group (P< 0.05). After treatment, CO and LVEF of two groups were higher than before treatment (P < 0.05), and CO and LVEF of the treatment group were higher than those of the control group (P < 0.05). After treatment, the levels of CD105 in two groups were higher than before treatment, while the levels of MMP-3 and Hcy were lower than before treatment (P < 0.05). After treatment, the levels of CD105 in the treatment group was higher than that in the control group, while the levels of MMP-3 and Hcy were lower than those in the control group (P < 0.05). After treatment, the levels of Lp-PLA2 and cTnT in two groups were lower than before treatment (P< 0.05). After treatment, the levels of Lp-PLA2 and cTnT in the treatment group were lower than those in the control group (P < 0.05). Conclusion Ginkgo Ketone Ester Dropping Pills combined with Benidipine Hydrochloride Tablets are effective in treatment of angina pectoris of coronary heart disease, which can significantly improve the therapeutic effect, alleviate angina symptoms and myocardial damage.