Patellar inward pushing method relieves knee osteoarthritis via regulating cytokines |
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| Institution: | 1. Joint Trauma Center, PLA 371 Center Hospital, Department of Orthopedics, 371 Hospital, Xinxiang Medical University, Xinxiang 453003, PR China;2. Department of Digestive System, PLA 371 Center Hospital, Xinxiang Medical University, Xinxiang 453003, PR China;1. Department of Nephrology & Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, CDMX, Mexico;2. Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, CDMX, Mexico;3. Renal Division and Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;4. Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Mexico;1. Department of Gastroenterology, The 940th Hospital of Joint Service Logistics Support Force of Chinese People''s Liberation Army, Lanzhou 730050, Gansu, China;2. The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China;1. Department of Pulmonology, St. Antonius Hospital, Nieuwegein/Utrecht, the Netherlands;2. Department of Medical Microbiology and Immunology, St. Antonius Hospital, Nieuwegein/Utrecht, the Netherlands;3. Science Department, University College Roosevelt, Middelburg, the Netherlands;4. Department of Pulmonology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands;1. School of Graduate, Hebei Medical University, Shijiazhuang, Hebei Province 050000, China;2. Department of Anesthesiology and Pain Medicine, Hebei General Hospital, Shijiazhuang, Hebei Province 050000, China;3. Cardiology Center, Hebei General Hospital, Shijiazhuang, Hebei Province 050000, China;4. Department of Surgery, Hebei General Hospital, Shijiazhuang, Hebei Province 050000, China |
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| Abstract: | BackgroundKnee osteoarthritis (KOA) is a chronic degenerative disease characterized by pain, morning stiffness and swelling in the knee joints. And KOA is common in the elderly and seriously affects the exercise function and physical health of patients. This study aimed to explore the curative effects of patellar inward pushing method (PIPM) on KOA.Material and methodIn this study, we established rabbit animal models of KOA for the research by using the New Zealand white rabbits. 30 New Zealand white rabbits were divided into 5 groups by random number table method: blank group, model group, glucosamine hydrochloride (GH) group, PIPM group and PIPM combined with GH group, then the rabbits were modeled.ResultsAfter 9-weeks cultured in groups, 5 ml blood was collected from the heart, and cytokines were detected. The result suggested that iNOS, NO and TNF-α were the pathogenic inflammatory factor of KOA, and aggravated cartilage damage and degeneration. Besides, this study indicated that PIPM combined with GH treatment significantly reduced the activity of inflammatory cytokines in serum and joint fluid of KOA models in rabbits. In addition, PIPM combined with GH therapy exhibited the best therapeutic effect among these treatments, which was working on KOA better than PIPM treatment alone or GH treatment alone.ConclusionsPIPM could effective treat KOA via regulating cytokines, and the PIPM combined with GH therapy could be a novel therapeutic strategy of KOA. |
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