High endothelial venules associated with better prognosis in esophageal squamous cell carcinoma |
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| Affiliation: | 1. Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China;2. State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center (SYSUCC), Guanghzou, China;3. Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China;1. Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA;2. Otolaryngology-Head and Neck Surgery, Medical College of Wisconsin, Milwaukee, WI, USA;3. Institute of Medical and Public Health Research, Ilia State University, Tbilisi, Georgia;1. Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan;2. Department of Hepatobiliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan;3. Department of Diagnostic Pathology, Fukui Prefecture Saiseikai Hospital, Fukui, Japan;4. Department of Surgery, School of Medicine, Nihon University, Tokyo, Japan;5. Department of Internal Medicine, Fukui Prefecture Saiseikai Hospital, Fukui, Japan;6. Department of Digestive Surgery, Fukui Prefecture Saiseikai Hospital, Fukui, Japan;7. Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan;8. Department of Digestive Internal Medicine, Shizuoka Medical Center, Shizuoka, Japan;9. Department of Human Pathology, Kanazawa University School of Medicine, Kanazawa, Japan;1. Department of Pathology, Genetics Service, Faculty of Medicine, University of Porto, Portugal;2. Medical Genetics Service, Centro Hospitalar Universitário de São João, Porto, Portugal;3. I3S-Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal;4. Department of Obstetrics and Gynecology, Centro Hospitalar Vila Nova Gaia/Espinho (CHVNG), Vila Nova de Gaia, Portugal;5. Department of Obstetrics and Gynecology, Hospital São João, Porto, Portugal;6. Obstetrics and Gynecology Service, Faculty of Medicine, Porto, Portugal;1. Department of Pathology, Changhai Hospital, Naval Military Medical University, Shanghai, China;2. Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Military Medical University, Shanghai, China;1. Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China;2. Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China;3. Medical Research Center, Shengjing Hospital of China Medical University, Shenyang, China |
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| Abstract: | BackgroundHigh endothelial venules (HEVs) are specialized microvessels for recruiting naïve T cells and B cells from the circulation into secondary lymphoid organs. Its involvement in esophageal squamous cell carcinoma (ESCC) is still unknown. This study mainly investigated the possible presence of HEVs in ESCC and explore its relationship with prognosis.MethodFormalin fixed paraffin embedded (FFPE) tissue samples of 52 ESCC patients were stained with immunohistochemically (IHC) to assess the association of HEVs with histological and clinical factors by immunohistochemistry. Furthermore, multiplexed immunofluorescence was performed to explore the microenvironment around HEVs.ResultHEVs was widely present in ESCC and was significantly associated with better overall survival (OS). In addition, multiplexed immunofluorescence imaging demonstrated that HEVs is mainly present in the tertiary lymphoid structures (TLS) of the tumor and is surrounded by a large number of lymphocyte cells.ConclusionHEVs represent a better prognostic factor in ESCC. |
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