Leukemia in donor cells after allogeneic hematopoietic stem cell transplant |
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| Authors: | Brunstein C G Hirsch B A Hammerschmidt D McGlennen R C Nguyen P L Verfaillie C M |
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| Affiliation: | Division of Hematology, Oncology and Transplantation, Department of Medicine University of Minnesota, Minneapolis, MN 55455, USA. |
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| Abstract: | The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34(+) cells. |
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