| 反相高效液相色谱法测定氯沙坦钾片的溶出度 |
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| 引用本文： | 高红,刘睿斌,刘俊敏.反相高效液相色谱法测定氯沙坦钾片的溶出度[J].中国药业,2010,19(8):33-34. |
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| 作者姓名： | 高红 刘睿斌 刘俊敏 |
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| 作者单位： | 重庆科瑞制药有限责任公司研发中心,重庆,400060 |
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| 摘 要： | 目的建立测定氯沙坦钾片溶出度的反相高效液相色谱法。方法采用十八烷基硅烷键合硅胶柱，流动相为甲醇-水（含0．05mol／L磷酸二氢钾，用磷酸调pH至3．2，64：36），流速为1．0mL／min。检测波长为250nm。结果线性范围为11．43～114．3μg／mL（r=0．9999），平均回收率为100．61％，RSD=1．03％（n=6）。结论该方法灵敏度高，简便易行，结果准确，重现性好，适用于氯沙坦钾片的溶出度测定。
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| 关 键 词： | 氯沙坦钾 溶出度 高效液相色谱法 |
Determination of Dissolution of Losartan Potassium Tablets by RP-HPLC |
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| Gao Hong,Liu Ruibin,Liu Junmin.Determination of Dissolution of Losartan Potassium Tablets by RP-HPLC[J].China Pharmaceuticals,2010,19(8):33-34. |
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| Authors: | Gao Hong Liu Ruibin Liu Junmin |
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| Institution: | ( Chongqing Kerui Pharmaceutical Co. , Ltd. , Chongqing, China 400060) |
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| Abstract: | Objective To develop a method for determining the dissolution of Losartan Potassium Tablets by RP-HPLC. Methods The Venusil XBP-C18 column was used with methanol-waters（containing 0.05 mol/L monopotassium phosphate, adjusting to pH of 3.2 with phosphoric acid,64：36） as the mobile phase. The flow rate was 1.0mL/min,and the detection wavelength was 250nm. Results The calibration curve was linear in the range of 11.43-114. 3μg/mL（r=0.999 9）. The average recovery rate was 100. 61%, RSD was 1.03% （n-6）. Conclusion This method is sensitive, simple,rapid and accurate with good reproducibility, which can be used to determine the dissolution of Losartan Potassium Tablets. |
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| Keywords: | losartan potassium dissolution HPLC |
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