99mTc-ECD SPECT SPM分析健康成人控尿状态下局部脑血流变化

目的 应用99mTc-双半胱乙酯(ECD)SPECT脑血流断层显像研究健康成人静息状态和控尿状态下脑血流的差异,定位控尿相关的大脑功能区.方法 对16名健康志愿者在静息状态下(排空膀胱)行SPECT脑血流断层显像后,注射呋塞米,在膀胱充盈状态应用同等条件再次显像,前后两次采集数据相减,获得控尿状态图像.采用统计参数图(SPM)软件进行分析.结果 在控尿状态下,右侧顶叶、双侧额上回、右侧额下回和右侧颞上回、左侧屏状核的脑血流明显增高.结论 正常生理状态下,大脑控尿与右侧顶叶、双侧额上回、右侧额下回、右侧颞上回和左侧屏状核密切相关.联合应用SPECT脑功能显像及SPM分析软件可以更方便、快捷地定位大脑功能区.

99mTc-ECD brain SPECT imaging and statistical parametric mapping observation on changes of regional cerebral blood flow under urine withholding state in normal adults

Objective To explore the difference of cerebral activation areas between resting state and urine withholding state in healthy subjects with SPECT using ^99mTc-ethyl cysteinate dimmer (^99mTc-ECD) as the cerebral perfusion agent, and to identify the cerebral activation areas related to urine control. Methods Sixteen healthy volunteers were recruited. All the subjects underwent brain perfusion scan with SPECT: Resting state with empty bladder and urine withholding state with full bladder. The images were analyzed with statistical parametric mapping (SPM). Results Under the urine withholding state, the cerebral perfusion increased significantly in the right parietal lobe, bilateral superior frontal gyrus, right inferior frontal gyri, right superior temporal gyri and the left claustrum. Conclusion The control of urinary continence in healthy subjects is associated with the right parietal lobe, bilateral superior frontal gyrus, right inferior frontal gyri and the left claustrum. The combination of brain perfusion SPECT and SPM is a convenience and shortout method to align the functional areas of the brain.