| MTS_1基因产物P_(16)蛋白在肾癌中的表达及意义 |
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| 引用本文： | 王固新,党建功,南勋义,刘庆勇. MTS_1基因产物P_(16)蛋白在肾癌中的表达及意义[J]. 现代泌尿外科杂志, 1998, 0(2) |
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| 作者姓名： | 王固新 党建功 南勋义 刘庆勇 |
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| 作者单位： | 深圳市福田医院泌尿外科，西安医科大学第一附院泌尿外科，西安医科大学第一附院泌尿外科，西安医科大学第一附院泌尿外科 深圳 518033 |
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| 摘 要： | 采用免疫组化法对42例肾癌、20例癌旁正常肾组织MTS_1基因产物P_(16)蛋白进行检测。结果显示肾癌P_(15)蛋白表达阳性率明显高于癌旁正常肾组织(P<0.01),P_(16)表达相关于肾癌病理分级、临床分级及预后。结果提示:MTS_1基因与肾癌的发生发展有关,P_(16)蛋白表达缺失是肾癌恶性度高及晚期表现。P_(16)蛋白表达可作为判断肾癌预后的指标。
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| 关 键 词： | MTS_1 基因 P_(16)蛋白 肾癌 |
The Expression and Significance of Multiple Tumor Suppressor 1 Gene Product in Human Renal cell Carcinoma |
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| Wang Guxin,Dang Jiangong,Nan Xunyi,et al. The Expression and Significance of Multiple Tumor Suppressor 1 Gene Product in Human Renal cell Carcinoma[J]. Journal of MOdern Urology, 1998, 0(2) |
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| Authors: | Wang Guxin Dang Jiangong Nan Xunyi et al |
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| Abstract: | The P16 protein which is the product of MTS1 gene was studied in 42 specimen of renal cell carcinoma and 20 specimen of normal tissue around renal carcinoma by immuno-histochemical techniques. The result indicated that the rate of P16 protein in renal carcinoma was higher than in normal tissues (P < 0. 01) . The expression of P16 was related to pathologic grade, clinical Robson stage and prognosis of RCC. The result suggest that MTS1 gene is related to occurance and development of RCC,and loss of P16 protein expression is a indicator of high malignance and late stage of RCC. The P16 protein expression can be used as a predictor of prognosis. |
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| Keywords: | MTS1 gene P16 protein renal cell carcinoma |
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