Different effects of electrical stimulation of the mesencephalic and pontine reticular formation on the release of dopamine and acetylcholine in the cat caudate nucleus |
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| Authors: | R Romo Y M Gaudry-Talarmain A Chéramy G Godeheu V Leviel M F Chesselet J Glowinski M Isra?l |
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| Institution: | 1. Chaire de Neuropharmacology, INSERM U 114, Collège de France, Paris France;2. Laboratoire de Neurobiologie Cellulaire et Moléculaire, Départment de Neurochimie, C.N.R.S., Gif sur Yvette France;1. Department of General Psychology, University of Padua, Italy;2. Esapolis’ Living Insects Museum, Padua, Italy;1. Dept. of Psychology Sciences, University of Connecticut, Storrs, CT 06269-1020, USA;2. Area de Psicobiol., Dept. Psic., Universitat de Jaume I, Castelló 12071, Spain;3. University of El Paso, El Paso, TX, USA |
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| Abstract: | The effects of unilateral electrical stimulation of the pontine (PRF) and mesencephalic (MRF) reticular formation on the release of acetylcholine (ACh) and of 3H]dopamine continuously synthesised from 3H]tyrosine were examined in both caudate nuclei of halothane-anaesthetised cats implanted with push-pull cannulae. Stimulation of PRF led to a prolonged bilateral increase in the release of 3H]dopamine, whereas a significant reduction in 3H]amine release was observed in the ipsilateral caudate nucleus following stimulation of the MRF. Changes in ACh release were also seen, but they seemed to be independent from those in dopamine release: the release of ACh was enhanced markedly in both caudate nuclei following stimulation of the MRF, whereas a more moderate increase in the release of ACh occurred ipsilaterally following stimulation of the PRF. These data indicate that both the MRF and the PRF are involved in the control of dopaminergic and cholinergic transmission in the basal ganglia. |
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