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Esophageal motility and gastric acid secretion in patients with Barrett's esophagus |
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| Authors: | Katsuhiko Iwakiri Yuriko Tanaka Noriyuki Kawami Makoto Kotoyori Yoshinori Hayashi Akihiko Kawakami Hiroshi Makino Tsutomu Nomura Masao Miyashita Kaiyo Takubo Choitsu Sakamoto |
| Affiliation: | (1) Department of Medicine, Division of Gastroenterology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan;(2) Department of Surgery, Division of Digestive Surgery, Nippon Medical School, Tokyo, Japan;(3) Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan |
| Abstract: | Patients with Barrett's esophagus (BE) usually have low resting lower esophageal sphincter (LES) pressure, and also have impaired esophageal body motility, with low amplitude and failed peristaltic contractions on swallowing being common. These motor abnormalities contribute to excessive esophageal acid exposure in patients with BE. However, gastric acid secretion is not different between patients with BE and reflux esophagitis. |
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