| 三苯氧胺对绝经期妇女内分泌的影响 |
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| 引用本文： | 李琳,刘洪健.三苯氧胺对绝经期妇女内分泌的影响[J].菏泽医学专科学校学报,1999,11(1):4-5. |
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| 作者姓名： | 李琳 刘洪健 |
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| 作者单位： | [1]菏泽医学专科学校生理学教研室274030 [2]菏泽地区人民医院 |
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| 摘 要： | 目的观察三苯氧胺对鲍经期妇女内分泌的影响，探讨三苯氧胺抗雌激素作用和类雌激素效应的形成机制；方法应用放射免疫法监测39名鲍经期女性乳腺癌患三苯氧胺治疗后血清雌激素浓度的变化；结果鲍经期妇女接受三苯氧胺治疗3个月后血清雌二醇、雌酮、脱氢表雄酮浓度均有不同程度的升高，以雌二醇的升高有显性(P<0．01)；结论三苯氧胺可引起鲍经期妇女血清雌激素浓度的升高，升高的雌激素可能缓解曼年期内分泌紊乱而出现的症状。
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| 关 键 词： | 三苯氧胺 绝经期妇女 内分泌变化 |
Endocrine Changes in Postmenopausal Women Using Tamoxifen |
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| Li Lin,Liu Hongjian.Endocrine Changes in Postmenopausal Women Using Tamoxifen[J].Journal of Heze Medical College,1999,11(1):4-5. |
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| Authors: | Li Lin Liu Hongjian |
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| Abstract: | Objective To observe the endocrine changes in postmenopausal women during Tamoxifen therapy. Methods We have checked the changes of serum estrogen levels in 39 postmenopausal women during Tamoxifen therapy using radiommunoassay. Results The serum estrogen levels in postmenopausal women significantly increased after three months'therapy. (P<0.01) Conclusion Tamoxien therapy can be associated with the increased serum estrogen levels. The increased serum estrogens may explain the effects of endocrine disorders in postmenopausal women. |
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| Keywords: | tamoxifen postmenopausal women endocrine changes |
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