双歧杆菌三联活菌胶囊联合早期肠内营养治疗重症急性胰腺炎患者的效果

目的:观察双歧杆菌三联活菌胶囊联合早期肠内营养治疗重症急性胰腺炎患者的效果。方法:选取100例重症急性胰腺炎患者作为研究对象,采用随机数字表法分为对照组和观察组各50例。对照组实施早期肠内营养支持,观察组在对照组基础上加用双歧杆菌三联活菌胶囊。比较两组疗效,临床症状缓解时间,治疗前后血清炎性因子、降钙素原(PCT)、营养指标水平以及并发症发生率。结果:观察组治疗总有效率为96.00%,高于对照组的80.00%,差异有统计学意义(P<0.05);观察组腹痛、恶心呕吐和发热缓解时间均短于对照组,差异有统计学意义(P<0.05);治疗前,两组C反应蛋白(CRP)、白细胞介素-6(IL-6)、PCT水平和肱三头肌皮褶厚度、上臂围、白蛋白、血红蛋白水平比较,差异均无统计学意义(P>0.05);治疗后,观察组CRP、IL-6和PCT水平均低于对照组,肱三头肌皮褶厚度、上臂围、白蛋白和血红蛋白水平均高于对照组,差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:双歧杆菌三联活菌胶囊联合早期肠内营养治疗重症急性胰腺炎患者可提高治疗总有效率和营养指标水平,降低血清炎性因子和PCT水平,以及缩短症状缓解时间的效果优于单纯早期肠内营养支持治疗效果。

Effects of Bifidobacterium triple viable capsules combined with early enteral nutrition in treatment of patients with severe acute pancreatitis

Objective:To investigate effects of Bifidobacterium triple viable capsules combined with early enteral nutrition in treatment of patients with severe acute pancreatitis.Methods:100 patients with severe acute pancreatitis were selected as the research objects,and were divided into control group and observation group by using the random number table method,each with 50 cases.The control group was given early enteral nutrition support,while the observation group was added with Bifidobacterium triple viable capsules on the basis of that of the control group.The curative effects,clinical symptom relief time,serum inflammatory factor levels,procalcitonin(PCT)level,nutritional index levels and the incidence of complications were compared between the two groups.Results:The total effective rate of treatment in the observation group was 96.00%,which was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).The relief times of abdominal pain,nausea and vomiting and fever in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Before the treatment,there were no significant differences in the levels of C-reactive protein(CRP),interleukin-6(IL-6),PCT,albumin and hemoglobin,triceps skinfold thickness and upper arm circumference(P>0.05).After the treatment,the CRP,IL-6 and PCT levels of the observation group were lower than those of the control group;the triceps skinfold thickness,upper arm circumference,and albumin and hemoglobin levels were higher than those of the control group;and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:Bifidobacterium triple viable capsules combined with early enteral nutrition in the treatment of the patients with severe acute pancreatitis can improve the total effective rate of treatment and the nutritional indicator levels,reduce the level of serum inflammatory factors and PCT,and shorten the symptom relief time.Moreover,it is superior to single early enteral nutrition support treatment.