胃癌微环境中树突状细胞浸润的临床意义

目的 探讨胃癌微环境中肿瘤浸润性树突状细胞(TIDC)与癌细胞浸润程度、淋巴结转移及患者术后存活时间的关系。方法 采用免疫组织化学方法,运用抗S-100检测100例胃癌组织中的TIDC,并分析其与临床病理参数及生存率的关系。结果 TIDC在胃癌组织中的阳性率为41.0％(41/100),其与癌细胞浸润程度无相关性(P>0.05)。56例有淋巴结转移的患者中,TIDC阳性者淋巴结转移率为56.1％,阴性者为43.9％,两者比较差异无显著性意义(P>0.05);第2站以上淋巴结转移率,TIDC阳性者为29.7％,而阴性者为70.3％,两者比较,差异有显著性意义(P<0.05)。TIDC阳性和阴性患者5年生存率分别为59.0％和37.7％,两者比较.差异有显著性意义(P<0.05)。结论 TIDC阳性与癌细胞浸润程度无相关性,但与第2站以上淋巴结转移和患者术后生存率密切相关。

Clinical significance of tumor infiltrating dendritic cell in gastric cancer microenvironment

Objective To investigate the relationshio of tumor infiltrating dendritic cell(TIDC) with tumor infiltration, lymph node metastasis and the survival rate of patient with gastric cancer after operation. Methods TIDC was detected with anti-S-100 monoclonal antibody by immunohistochemical staining, and it's relationships with pathological parameters and survival were analyzed. Results The positive rate of TIDC expression in gastric cancer was 41.0% (41/100). There were no significant correlation between the positive expression of TIDC with tumor infiltration (P>0.05). The positive rate of TIDC was 56.1% in the patients with lymph node metastasis, and 43.9% in those without lymph node metastasis(P>0.05). There was significant difference in S-100 expression between the patients with and without No2 lymph node metastasis. The 3-year survival rate was 59.3% in the patients with positive TIDC, and significantly more than 37.7% in those with negative TIDC (P<0.05). Conclusions There is no correlation between positive TIDC and tumor infiltration. However, There are significant differences in No. 2 lymph node metastasis and survival between the patients with positive and negative TIDC.