| 儿童脑胶质瘤Ki-67抗原表达及其意义 |
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| 引用本文： | 鲍为群,蔡嘉琳,吴洁,鲍克容.儿童脑胶质瘤Ki-67抗原表达及其意义[J].临床儿科杂志,2009,27(6). |
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| 作者姓名： | 鲍为群 蔡嘉琳 吴洁 鲍克容 |
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| 作者单位： | 上海交通大学医学院附属新华医院儿内科神经组,上海,200092 |
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| 摘 要： | 目的 研究Ki-67抗原在儿童脑胶质瘤中的表达与不同病理分类分级、肿瘤生长部位的关系.方法 对62例不同病理分类分级的儿童脑胶质瘤进行Ki-67免疫组织化学染色,观察Ki-67标记指数及染色程度.结果 胚胎性肿瘤的Ki-67标记指数(Ki-67 LI)显著高于其他腩胶质瘤(P<0.05);幕上胶质瘤的Ki-67 LI显著低于幕下胶质瘤(P<0.05);Ki-67 LI随脑胶质瘤恶性程度级别增高呈上升趋势,其中Ⅰ、Ⅱ、Iil级的Ki-67 LI显著低于Ⅳ级(P<0.05),且Ⅰ级的Ki-67 LI显著低于Ⅲ级(P<0.01);低级别胶质瘤(Ⅰ级和Ⅱ级)的Ki-67 LI显著低于高级别胶质瘤(Ⅲ级和Ⅳ级)(P<0.01);低级别胶质瘤(Ⅰ级和Ⅱ级)的Ki-67阳性细胞核染色程度明显弱于高级别胶质瘤(Ⅲ级和Ⅳ级)(P<0.01).结论 Ki-67抗原是反映儿童脑胶质瘤细胞增殖活性较可靠的细胞增殖指标,可以为小儿脑胶质瘤病理分类分级提供一种有效的辅助方法,有助于更加客观地评价息儿的预后.
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| 关 键 词： | 脑胶质瘤 Ki-67抗原 免疫组织化学 儿童 |
Expression and significance of Ki-67 antigen in pediatric brain glioma |
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| BAO Wei-qun,CAI Jia-lin,WU Jie,BAO Ke-rong.Expression and significance of Ki-67 antigen in pediatric brain glioma[J].The Journal of Clinical Pediatrics,2009,27(6). |
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| Authors: | BAO Wei-qun CAI Jia-lin WU Jie BAO Ke-rong |
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| Institution: | Department of Pediatrics;Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine;Shanghai 200092;China |
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| Abstract: | Objective To study the relationship between the expression of Ki-67 antigen and the differences in pathological types, grades, and locations of pediatric brain glioma. Methods Sixty-two samples of glioma with various pathological types and grades were examined by labeling index and staining intensity of Ki-67 with immunohistochemical technique. Results The expression of Ki-67 LI in supratentorial gliomas was significantly lower than those in subtentorial gliomas (P < 0.05). The expression of Ki-67 LI increa... |
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| Keywords: | brain glioma Ki-67 antigen immunohistochemistry children |
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