bag-1和Chemerin在肺癌临床诊断中的意义

目的评价肺癌患者血清bag-1和Chemerin在临床诊断中的意义。方法采用ELISA法对2009年1月至2011年12月在本院胸心外科接受手术治疗经病理组织检查确诊的56例I～Ⅱ期肺癌患者和60名健康体检者的外周血清进行bag．1、Chemerin蛋白浓度检测。结果肺癌患者外周血bag．1和Chemerin的浓度分别为（32．53±4．22）pg／ml、（54．61±6．78）pg／ml，显著高于健康体检者的（9．49±2．72）pg／ml、（10．23±4．74）pg／ml，差异有统计学意义（P〈0．01）。诊断肺癌bag-1和Chemerin的灵敏度分别为63．5％、67．3％，特异度分别为57．2％、60．4％，阳性拟然比分别为1．48、1．70。两者联合检测的灵敏度、特异度、阳性拟然比分别为89．7％、91．9％、11．07，均高于单检的灵敏度、特异度、阳性拟然比，差异有统计学意义（P〈0．05）。结论bag-1和Chemerin在肺癌诊断中有较高的临床价值。

The significance of bag-1 and chemerin in the diagnose of lung cancer

Objective The evaluation of bag-1 and chemerin in the diagnose of lung cancer. Method bag-1 and chemerin were detected in the serum samples of 56 lung cancer （ I - II ）patients with cardiothoracic surgery and 60 healthy individuals from January, 2009 to December, 2011. Results The levels of bag-l（32.53±4.22）pg/ml and chemerin （54.61±6.78）pg/ml in the 56 lung cancer patient serum samples were higher than those in 60 healthy individuals （9.49±2.72）pg/ml, （10.23± 4.74）pg/ml, P〈0.01 ]. The sensitivities and specificities of bag-I and ehemerin were 63.5% and 57.2%, and 67.3% and 60.4%, respectively, with the masculine likelihood ratio of 1.48 and 1.70, respectively. The sensitivity and the specificity and the masculine likelihood ratio of the double marker diagnosis using both bag-1 and chemerin were 89.7%, 91.9% and 11.07, respectively and were higher than those using single marker（P〈0.05 ）. Conclusion bag-1 and chemerin are important serum markers for diagnosis of lung cancer.