丁苯酞及针刺联合高压氧治疗急性一氧化碳中毒后迟发性脑病的疗效观察

目的探讨丁苯酞及针刺联合高压氧治疗急性一氧化碳中毒后迟发性脑病的临床疗效。方法将符合标准的120例患者随机分为研究组和对照组，每组60例。研究组在高压氧等常规治疗的基础上加用丁苯酞及针刺治疗，对照组给予高压氧等常规治疗。观察和比较两组治疗效果及治疗前后MMSE评分、脑电图变化。结果研究组简易智能精神量表评分及脑电图与对照组比较差异有统计学意义（P〈0．05），研究组能明显改善MMSE评分且脑电图异常率比对照组低；研究组在痊愈率和总有效率方面显著优于对照组，差异有统计学意义（P〈0．05）。结论丁苯酞及针刺联合高压氧治疗急性一氧化碳中毒后迟发性脑病可以提高患者的治疗效果和生存质量，有良好的临床应用价值。

Curative effect of butylphthalide and acupuncture combined with hyperbaric oxygen on the treatment of delayed encephalopathy after acute carbon monoxide poisoning

Objective To study the curative effect of butylphthalide and acupuncture combined with hyperbaric oxygen on the treatment of delayed encephalopathy after acute carbon monoxide poisoning. Methods 120 cases patients were randomly divided into treatment group and the control group （n=60）. In hyperbaric oxygen treatment group, apart from the conventional treatment butylphthalide soft capsule were given orally 3 times a day and 200 mg/time together with acupuncture treatment, while the control group was given routine hyperbaric oxygen treatment. Results Statistical analysis showed that after treatment the treatment group cure rate and total effective rate were significantly better than those in control group （P〈0.05）. In the treatment group, simple intelligent scale score and electroencephalogram （eeg） results were significantly different from those of the control group （P〈O.05） ; in the treatment group the MMSE score was significantly improved and eeg abnormal rate was significantly lower than that of the control group. Conclusion Butylphthalide and acupuncture combined with hyperbaric oxygen therapy in patients with delayed encephalopathy after acute carbon monoxide poisoning can improve therapeutic effect and quality of life, has the good clinical application value and is worth popularizing in clinical practice.