宫颈病变患者阴道局部免疫功能的变化与HPV转归的研究进展

持续的人乳头状瘤病毒（HPV）感染是发生宫颈病变的高危因素。在宫颈HPV感染及宫颈病变发生、发展的过程中，阴道局部的体液免疫及细胞免疫是抵抗病毒感染及病变发生的第一道防线，也与肿瘤的发生、发展有着密切的联系。其中细胞免疫发挥着主要的抗病毒及减少病毒复制作用，同时体液免疫也在这个过程中发挥着重要的协同作用。在HPV感染引起的宫颈病变治疗前后，阴道局部的体液免疫及细胞免疫功能也会同时发生变化，免疫功能的变化提示预后以及HPV转归的情况，在宫颈病变发生前或发生过程中，有目的地增强患者的免疫功能是否能为疾病的预防及治愈起到指导作用是研究的重要方向。综述HPV感染引起的宫颈病变患者治疗后免疫功能的变化与HPV转归的最新研究进展。

Local Immune Function of Vagina and HPV Outcome in Patients with Cervical Lesions

The persistent infection of HPV is a risk factor of cervical lesions. The local humoral immunity and cellular immunity are the first defense against the viral infection and disease progression during the cervical infection of HPV and cervical lesions, which is related to the pathogenesis and progression of tumor. The local cellular immune plays main roles in antiviral and inhibition of viral replication, while the local humoral immunity has an important synergistic effect. The vaginal local humoral immune and cellular immune function are changed by HPV infection before and after treatment of cervical lesions, suggesting that the local immune function could be a marker of the HPV outcome and the prognosis of cervical lesions. It is necessary to study whether it is possible to improve the immune function as the adjuvant prevention and treatment of cervical lesions. We discussed here the vaginal local immune function, and the HPV outcomes, in those patients with cervical lesions after treatment.