人白细胞介素-21及其受体的研究进展

 人白细胞介素(interleukin, IL)21（IL-21）是一种由CD4⁺ T细胞、自然杀伤细胞、17型辅助性T细胞等分泌的I型细胞因子。IL-21受体是一种典型的I型细胞因子受体，在大部分骨髓细胞、淋巴细胞等表面都有表达。IL-21与IL-21受体结合可对机体免疫应答产生广泛的影响。IL-21具有抗肿瘤作用，IL-21与其他细胞因子、抗体、疫苗联用是一种有效的肿瘤治疗方法。

Development on research of human interleukin-21 and its receptor

 Human interleukin-21(IL-21) is a typeⅠcytokine produced by CD4⁺ T cell, natural killer cell and T helper 17 cell. IL-21 receptor (IL-21R) is a typical type I cytokine receptor, and can be expressed on most of bone marrow cells and lymphocytes. The binding of IL-21 and IL-21R has broad effects on both innate and adaptive immune responses. IL-21 has anti-tumor activity, and the strategy of combining IL-21 with other cytokines, antibodies, and vaccines is an effective and hopeful method on tumor theroputic.