Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes: inhibitory role of C. albicans germination |
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| Authors: | Liu L Kang K Takahara M Cooper K D Ghannoum M A |
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| Affiliation: | The Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio. |
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| Abstract: | The role of Candida albicans yeast-to-hyphae transition in interleukin-12 (IL-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induced by heat-killed C. albicans. Comparison of the abilities of germinating C. albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. albicans plays a critical role in the inhibition of IL-12 production. |
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