| 微量白蛋白尿与血浆高敏C反应蛋白的关系 |
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| 作者姓名： | Yan JT Ye H Wang DW |
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| 作者单位： | 430030,武汉,华中科技大学同济医学院附属同济医院内科 |
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| 基金项目： | 国家重点基础研究发展规划(973)项目资助(G2000056901) |
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| 摘 要： | 目的探讨微量白蛋白尿(MA)与血浆高敏C反应蛋白(hsCRP)水平的关系。方法采用ELISA的方法分别对746名国人血浆hsCRP和尿微量白蛋白水平进行检测,并进行统计学分析。结果MA组血浆hsCRP水平显著高于对照组(2.23±3.35)mg/L比(1.68±2.58)mg/L,P<0.05];血浆hsCRP水平超过0.77mg/L时,MA的发生率明显增加(P<0.05);MA的发生与hsCRP水平成正相关(OR=1.153,P<0.05)。结论hsCRP水平升高可能参与MA的发生,提示炎症反应可能具有促进内皮功能损害的作用。
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| 关 键 词： | 微量白蛋白尿 血浆 高敏C反应蛋白 心血管疾病 血管炎症 动脉粥样硬化 |
| 修稿时间： | 2005年3月5日 |
The relationship between microalbuminuria and plasma high sensitivity C reactive protein |
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| Yan JT,Ye H,Wang DW.The relationship between microalbuminuria and plasma high sensitivity C reactive protein[J].Chinese Journal of Cardiology,2005,33(6):534-535. |
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| Authors: | Yan Jiang-tao Ye Hui Wang Dao-wen |
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| Institution: | Department of Internal Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. |
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| Abstract: | OBJECTIVE: To investigate the relationship between microalbminuria (MA) and plasma high sensitivity C reactive protein (hsCRP). METHOD: The plasma hsCRP level and urine albumin level of 746 Chinese people were detected with ELISA and analyzed, respectively. RESULT: The hsCRP level of MA group increased significantly compared with the control group (2.23 +/- 3.35 mg/L vs 1.68 +/- 2.58 mg/L, P < 0.05), the incidence of MA increased significantly when the plasma hsCRP level was beyond 0.77 mg/L (P < 0.05); logistic analysis showed that the occurrence of MA was associated with the plasma hsCRP level (OR = 1.153, P < 0.05). CONCLUSION: Increased plasma hsCRP was probably involved in the occurrence of MA, suggesting that inflammation may deteriorate endothelial dysfunction. |
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| Keywords: | Albuminuria C-reactive protein Risk factor |
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