不同方案新辅助化疗对乳腺癌激素受体表达的影响

目的 探讨不同方案新辅助化疗对乳腺癌激素受体表达的影响.方法 免疫组化检测不同方案新辅助化疗组的乳腺癌患者化疗前后肿瘤组织雌激素受体(estrogen receptor,ER)和孕激素受体(progesterone receptor, PR)的表达情况,并比较两组化疗前后ER和PR表达水平的差异.结果 TE方案新辅助化疗组60例,ER表达水平增强15例(25.0%),减弱8例(13.3%),PR表达水平增强12例(20.0%),减弱6例(10.0%);CEF方案新辅助化疗组57例,ER表达水平增强8例(14.0%),减弱4例(7.0%),PR表达水平增强6例(10.5%),减弱3例(5.3%).TE方案新辅助化疗前后ER、PR表达水平改变显著(P＜0.05),而CEF方案新辅助化疗前后改变不显著(P＞0.05),不同疗效病例组之间ER、PR的表达水平改变差异显著(P＜0.05).结论 TE方案新辅助化疗对乳腺癌患者的ER、PR表达水平的改变影响显著,而CEF方案新辅助化疗对乳腺癌患者ER、PR表达水平的改变无明显影响,化疗后ER、PR表达水平的改变与疗效有关.

Influence of neoadjuvant chemotherapy of different regimen on expression of hormonal receptors in breast cancer

Objective To study the expression changes of hormonal receptors in breast cancer after neoadjuvant chemotherapy of different regimen. Methods The expressions of estrogen receptor (ER) and progestrone receptor (PR) were examined by immunohistochemical assay in tissue samples of breast cancer before and after neoadjuvant chemotherapy of two different regimens CTX EPI 5-Fu (CEF) vs TAX EPI (TE)]. The difference between the two regimens was compared. Results After neoadjuvant chemotherapy, in 60 cases of TE regimen, the ER expression increased in 15 cases (25.0%) and decreased in 8 cases (13.3%), the PR expression increased in 12 cases (20.0%) and decreased in 6 cases (10.0%); in 57 cases of CEF regimen, the ER expression increased in 8 cases (14.0%) and decreased in 4 cases (7.0%), the PR expression of increased in 6 cases (10.5%) and decreased in 3 cases (5.3%). The ER and PR expressions in TE regimen increased significantly after neoadjuvant chemotherapy (P<0.05), but they were of no significant changes in CEF regimen (P>0.05). The expression changes of ER and PR were of significant difference between TE regimen and CEF regimen (P<0.05). Conclusion The expressions of ER and PR were influenced by neoadjuvant chemotherapy of TE regimen significantly, but insignificantly by that of CEF regimen. The expression changes of hormonal receptor are related to the effect of neoadjuvant chemotherapy.