慢性阻塞性肺疾病患者血浆内皮素-1含量与肺功能变化的研究

目的 探讨慢性阻塞性肺疾病(COPD)患者血浆内皮素(ET)-1含量与肺功能变化的关系.方法 选择健康体检者30例为A组,选择34例COPD急性发作期患者为B组,患者治疗后病情缓解期为C组,分别在治疗前后测定血浆ET-1含量,并行动脉血气及肺功能检查.结果 B、C组患者血浆ET-1含量显著高于A组,与PaO2:呈负相关,且与PaCO2呈正相关,P值均＜0.01.B组患者肺功能参数(VC、FEV1/FVC、MVV、V50、V25)明显低于A组和C组分别为(55.3±24.5)%、(54.8±19.3)%、(54.2± 416.2)%、(54.8±9.9)%、(58.7±14.5)%与(114.8±24.1)%、(84.9±21.6)%、(86.4 ±17、2)%、(78.5±14.8)%、(90、3.±15.4)%和(110.1±19.4)%、(85.8 ±15.5)%、(85.9 ±16.7)%、(74.5±13.4)%、(89.4±18.6)%],P值均＜0.01.结论 血浆ET-1、缺氧、CO2:潴留共同参与COPD病理生理的调节作用,从而影响肺功能变化.

The study on the change of plasma endothelin-1 related with pulmonary function in patients with chronic obstructive pulmonary disease

Objective To explore the relationship of content of plasma endothelin(ET)-1 with the change of pulmonary function in patients with chronic obstructive pulmonary disease(COPD).Method Thirty cases of the normal people were as group A ,34 cases of the patients with COPD with acute exacerbation before treatment were as group B and the patients with remission period after treatment were as group C,the plasma ET-1,arterial blood gas and pulmonary function parameters were determined from the patients before and after treatment.Results The plasma ET-1 in group B and group C were significantly higher than that in group A,the content of the plasma ET-1 had negatively correlated with PaO2,and that had positively correlated with PaCO2,P＜0.01.The pulmonary function parameters (VC,FEV1/FVC,MVV,V50 V25)in group B were significantly lower than those in group A and group C(55.3±24.5)%,(54.8±19.3)%,(54.2±16.2)%,(54,8±9,9)%,(58.7±14.5)%;(114.8±24.1)%,(84.9±21.6)%,(86.4±17.2)%,(78.5±14.8)%,(90.3±15.4)% and (110.1±19.4)%,(85.8±15.5)%,(85.9±16.7)%,(74.5±13.4)%,(89.4±18.6)%,respectively],P＜0.01.Conclusion Pathophysiological effects of patients with COPD can be commonly adjusted by the plasma ET-1,oxygen and carbon dioxide retention,which affect pulmonary function.