| 鲍曼不动杆菌Ⅰ类整合子系统与其耐药性关系的研究 |
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| 引用本文： | 阳大庆,唐银,李太存,石丽萍.鲍曼不动杆菌Ⅰ类整合子系统与其耐药性关系的研究[J].临床检验杂志,2006,24(5):338-340. |
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| 作者姓名： | 阳大庆 唐银 李太存 石丽萍 |
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| 作者单位： | 湖南怀化医学高等专科学校中南大学湘雅医院检验科;中南大学湘雅医院检验科;湖南省疾病预防与控制中心,长沙,418000;湖南怀化医学高等专科学校 |
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| 摘 要： | 目的了解Ⅰ类整合子系统在鲍曼不动杆菌中的分布状况,探讨其与该菌耐药性之间的关系。方法用琼脂稀释法测定鲍曼不动杆菌对14种抗生素的敏感性。用PCR法检测Ⅰ类整合子系统。结果29.2%(21/72)的菌株检测出Ⅰ类整合子系统。含与不含Ⅰ类整合子系统的菌株在耐药性上存在显著性差异(P<0.05)。不同类型Ⅰ类整合子的耐药表型存在一定的差异。结论Ⅰ类整合子系统与鲍曼不动杆菌多重耐药性以及耐药表型之间有密切的关系。
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| 关 键 词： | 鲍曼不动杆菌 基因盒 Ⅰ类整合子 耐药性 |
| 文章编号： | 1001-764X(2006)05-0338-03 |
| 收稿时间： | 2005-12-05 |
| 修稿时间： | 2006-06-01 |
Association of class 1 integrons of Acinetobacter baumannii with resistance |
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| YANG Daqing,TANG Yin,LI Taicun,SHI Liping.Association of class 1 integrons of Acinetobacter baumannii with resistance[J].Chinese Journal of Clinical Laboratory Science,2006,24(5):338-340. |
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| Authors: | YANG Daqing TANG Yin LI Taicun SHI Liping |
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| Institution: | Huaihua Medical College, Huaihua, Hunan 418000, China |
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| Abstract: | Objective To monitor the distribution of class 1 integrons of Acinetobacter baumannii and interpret the association of class 1 integrons with the resistance in clinical isolates.Methods Susceptibility to 14 different antimicrobial agents was determined by agar dilution method.DNA of all clinical isolates was extracted to detect class 1 integrons by PCR.Results The differences between integron-positive isolates and integron-negative isolates was significant in the resistance to all tested antibiotics except for Imipenem,Cefepime and Cefoperazone plus Sulbactam.Different types of class 1 integrons showed different resistance types.Conclusions There were some close relations of class 1 integrons with multi-drug resistance as well as resistance types in Acinetobacter baumannii. |
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| Keywords: | Acinetobacter baumannii gene-cassette class 1 integron resistance |
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