Significant differences in drug susceptibility among species in the Candida parapsilosis group |
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| Authors: | van Asbeck Eveline Clemons Karl V Martinez Marife Tong Ann-Jay Stevens David A |
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| Institution: | Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128, USA. |
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| Abstract: | Candida parapsilosis family has 3 proposed species: C. parapsilosis sensu stricto, Candida orthopsilosis, and Candida metapsilosis. C. parapsilosis sensu stricto had significantly higher caspofungin (CAS) and anidulafungin MICs than C. orthopsilosis or C. metapsilosis; C. metapsilosis was least susceptible to fluconazole. C. parapsilosis sensu stricto more frequently displayed (37%) paradoxical growth in CAS (P < or = 0.02). These species susceptibility differences could affect therapeutic choices. |
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| Keywords: | Candida parapsilosis Fluconazole Caspofungin Anidulafungin Susceptibility |
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