垂体细胞瘤临床病理观察

目的 探讨垂体细胞瘤的临床病理学特点及诊断要点.方法 对2例垂体细胞瘤的临床资料、影像学、病理形态学及免疫组化结果进行分析,并结合文献探讨其诊断及鉴别诊断.结果 2例患者的头颅MRI提示鞍区占位.镜下可见短梭状双极梭形细胞成分,细胞密度较低,排列稀疏,呈纤维束状排列,细胞核圆形或伸长形,局部可见血管结构,未见核分裂.免疫组化:vimentin、S-100和GFAP均(+)、Ki-67增殖指数＜1％,NEU-N和EMA均(-).结论 垂体细胞瘤起源于成人神经垂体或漏斗,较为罕见,由梭形细胞构成,生长缓慢,需与正常漏斗组织、毛细胞星形细胞瘤、梭形嗜酸细胞瘤等进行鉴别诊断.

Clinicopathologic analyses of pituicytoma

Objective To explore the clinical and pathological characteristics and diagnostic criteria of pituicytoma.Methods The clinical data,radiological,histopathologic changes and immunohistochemical staining were studied in 2 cases of pituicytoma;its diagnosis and differential diagnosis were discussed with review of the relevant literature.Results Case 1 was a 26-year-old female,and Case 2,a 25-year-old male.Cranial MRI showed an occupying lesion in saddle space.Microscopy showed a short bipolar spindle-like spindle cell component which had a lower cell density,sparse arrangement like glial fiber bundle and vascular structures were seen locally.No mitosis was found.Immunohistochemical staining showed that the tumors were positive for vimentin,S-100,GFAP,vimentin,and Ki-67(+<1%),but negative for NEU-N and EMA.Both of these cases were diagnosed as pituitary tumor,WHO gradeⅠ.Conclusion Pituicytoma originates in the adult pituitary or infundibulum.Pituicytoma is rare and composed of low-grade spindle cells with slow growth.It is necessary to be differentiated from normal infundibulum tissue,pilocytic astrocytoma and spindle cell oncocytoma.