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| 替米沙坦对高血压病患者血管内皮功能的影响 | |
| 引用本文： | 邬贤斌,孙秀才,许燕山. 替米沙坦对高血压病患者血管内皮功能的影响[J]. 实用预防医学, 2004, 11(3): 467-468 |
| 作者姓名： | 邬贤斌 孙秀才 许燕山 |
| 作者单位： | 1. 怀化医学高等专科学校,中国湖南,怀化,418000 2. 怀化市一医院心内科 3. 怀化医学高等专科学校附属医院 |
| 摘 要： | 目的 探讨替米沙坦对高血压病患者血管内皮功能的影响。方法 46例轻、中度原发性高血压患者，给予替米沙坦80mg／d，共6周。观察治疗前后的血浆内皮素-1(ET-1)和-氧化氮(NO)水平的变化。另设40例为健康对照组。结果 高血压病患者治疗前与对照组比较，其血浆ET-1水平明显升高，NO水平显著降低；经替米沙坦治疗后其ET-1明显下降，NO水平显著升高，与治疗前差别有显著性。结论 替米沙坦能改善高血压病患者的血管内皮功能。 |
| 关 键 词： | 替米沙坦 原发性高血压 血管内皮功能 |
| 文章编号： | 1006-3110(2004)03-0467-02 |
| 修稿时间： | 2004-03-01 |
Effect of Telmisartan on Vascular Endothelial Function in Patients with Essential Hypertension |
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| WU Xian-bing,SUN Xiu-cai,XU Yan-shang.. Effect of Telmisartan on Vascular Endothelial Function in Patients with Essential Hypertension[J]. Practical Preventive Medicine, 2004, 11(3): 467-468 | |
| Authors: | WU Xian-bing SUN Xiu-cai XU Yan-shang. |
| Abstract: | Objective To investigate the effect of Telmisartan on vascular endothelial function in patients with essential hypertension. Methods Forty-six patients with essential hypertension had been treated with 80mg Telmisartan per day for 6 weeks . Plasma ET-1 and NO were measured before and 6 weeks after treatment . Forty healthy adults served as controls. Result Before medication , ET-1 was higher and NO lower in treatment group than control group (P<0.05). In treatment group , ET-1 was significantly decreased and NO was significantly increased 6 weeks after treatment with Telmisartan (P<0.05) There was significant difference before and after treatment. Conclusion Telmisartan may improve the vascular endothelial function of patients with essential hypertension . |
| Keywords: | Telmisartan Essential hypertension Vascular endothelial function |
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