In vitro antiplasmodial activity of some plants used in Kisii,Kenya against malaria and their chloroquine potentiation effects |
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| Authors: | Muregi F W Chhabra S C Njagi E N M Lang'at-Thoruwa C C Njue W M Orago A S S Omar S A Ndiege I O |
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| Affiliation: | Biochemistry Department, Kenyatta University, PO Box 43844, Nairobi, Kenya. |
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| Abstract: | Fifty-five organic and aqueous extracts of 11 plants used in malaria therapy in Kisii District, Kenya were tested in vitro against chloroquine (CQ)-sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 73% were active (IC(50) < 100 microg/ml). Three plants, Vernonia lasiopus, Rhamnus prinoides and Ficus sur afforded extracts with IC(50) values ranging less than 30 microg/ml against both CQ-sensitive and resistant strains. Combination of some extracts with CQ against the multi-drug resistant P. falciparum isolate V1/S revealed some synergistic effect. The plant extracts with low IC(50) values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ. |
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