| 开普拓5-FU/CF治疗晚期结直肠癌临床观察 |
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| 引用本文： | 郭晓葵.开普拓5-FU/CF治疗晚期结直肠癌临床观察[J].医药论坛杂志,2009(12). |
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| 作者姓名： | 郭晓葵 |
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| 作者单位： | 苏州大学附属第二医院肿瘤科; |
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| 摘 要： | 目的观察CPT-11(开普拓)联合5-FU/CF治疗晚期结直肠癌的临床疗效和毒副反应。方法入组患者27例均为手术后局部复发和转移的晚期结直肠癌,经FOLFIRI方案化疗二个疗程(共4次)后,评价疗效,按照WHO实体瘤近期客观疗效评定标准进行评价。结果全组27例均可评价疗效及不良反应。完全缓解(CR)为0,部分缓解(PR)为6例(6/27),总有效率(CR+PR)达22%,疾病稳定(SD)16例(16/27)59.26%,疾病控制率(CR+PR+SD)为81.48%,疾病进展(PD)5例(5/27)18.52%。中位疾病进展时间为7.1个月(5～26个月),中位生存时间9.2个月。不良反应主要是消化道反应和骨髓抑制,以延迟性腹泻为多见,有8例为Ⅰ/Ⅱ度,Ⅲ/Ⅳ度仅1例,有4例Ⅰ/Ⅱ度骨髓抑制,Ⅲ/Ⅳ度骨髓抑制仅2例,无治疗相关的死亡。结论开普拓联合5-FU/CF治疗晚期结直肠癌近期疗效确切,不良反应可控制,临床上可大胆应用。
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| 关 键 词： | 晚期结直肠癌 开普拓（CPT-11） 化疗 |
Clinical Observation on CPT-11 Combined with 5-FU/CF in Patients with Advanced or Metastatic Colorectal Cancer |
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| GUO Xiaokui.Clinical Observation on CPT-11 Combined with 5-FU/CF in Patients with Advanced or Metastatic Colorectal Cancer[J].Journal of Medical Forum,2009(12). |
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| Authors: | GUO Xiaokui |
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| Institution: | GUO Xiaokui Department of Oncology,Second Affiliated Hospital of Suzhou University,Suzhou 215004,China |
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| Abstract: | Objective To observe the effect and toxicity of campto(CPT-11) combined with 5-FU/CF in patients with advanced or metastatic colorectal cancer.Methods Twenty-seven patients with local recurrence after surgery and advanced or metastatic colorectal cancer were included to receive FOLFIRI regimen biweekly(irinotecan 180mg/m2 on day1,5-FU 400mg/m2 iv bolus on day1,2 and 600mg/m2 iv continuous infusion 22-hours on day1,2 with CF 200mg/m2 administrated 2-hour before 5-FU infusion).They were assessed on the basis ... |
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