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| 顺铂药效和毒性作用的依时特征 | |
| 引用本文： | 刘广宣,杨立夫,张炳仁,徐峰. 顺铂药效和毒性作用的依时特征[J]. 中国医院药学杂志, 2004, 24(10): 609-610 |
| 作者姓名： | 刘广宣 杨立夫 张炳仁 徐峰 |
| 作者单位： | 1. 辽宁省肿瘤医院,辽宁,沈阳,110042 2. 沈阳医学院附属医院,辽宁,沈阳,110024 3. 沈阳药科大学,辽宁,沈阳,110016 |
| 摘 要： | 目的:探索顺铂药效和毒性依时特征.方法:通过监测S180实体瘤小鼠的瘤重、外周血尿素氮和LD50评价昼夜不同时间顺铂给药的反应.结果:顺铂凌晨2:00给药作用强、毒性大,晚上18:00给药毒性小,作用弱.结论:顺铂的药效和毒性反应同步运行,对于小鼠晚上给药不良反应小,提示顺铂临床用药应避开毒性反应最大的时间. |
| 关 键 词： | 顺铂 时间药理学 抗癌药 |
| 文章编号： | 1001-5213(2004)10-0609-02 |
| 修稿时间： | 2003-11-22 |
Time dependent characteristics of the effect, druga dverse reaction and toxicity of cisplatin |
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| LIU Guang-xuan,YANG Li-fu,ZHANG Bing-ren,XU Feng. Time dependent characteristics of the effect, druga dverse reaction and toxicity of cisplatin[J]. Chinese Journal of Hospital Pharmacy, 2004, 24(10): 609-610 | |
| Authors: | LIU Guang-xuan YANG Li-fu ZHANG Bing-ren XU Feng |
| Abstract: | OBJECTIVE To investigate the time dependent characteristics of the effect, drug adervse reaction and toxicity of cisplatin.METHODS S 180 tumor were transplanted to mice, the weight of tumor was weighed, blood BUN was determined by urinase UV velocity method, and LD50 of cisplatin in mice was evaluated in circadian time. RESULTS Cisplatin used at 2:00 got the strong action and toxicity, However, the effect, drug adverse reaction and toxicity were lower at 18:00 in the evening.CONCLUSION The tumor inhibit effect, drug adverse reaction and toxicity of cisplatin may change synchronize with the circadian time. It suggested that the administration time of cisplatin should be selected avoiding the time of high toxicity. |
| Keywords: | cisplatin chronopharmacology anti-cancer drug. |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |