盐酸左氧氟沙星滴耳液治疗中耳炎的疗效观察

目的:评价盐酸左氧氟沙星滴耳液治疗中耳炎的有效性和安全性。方法:采用同类有效药物氧氟沙星滴耳液作为对照,进行随机、双盲、阳性药物平行对照、多中心临床试验。结果:完成试验方案的可供疗效分析的患者120例,试验组和对照组各60例。试验组有效率为96.67%,细菌清除率为96.15%;对照组分别为85.00%和95.83%,两组差异无统计学意义(P均>0.05)。结论:盐酸左氧氟沙星滴耳液治疗中耳炎疗效显著,细菌清除率高,安全性好,与氧氟沙星滴耳液疗效相近。

Efficacy of levofloxacin ear drop in the treatment of otitis media

Objective: To observe the efficacy and safety of the levofloxacin ear drop in the treatment of otitis media.Method: A randomized,double-blind,multicenter,ofloxacin ear drop controlled trial was performed.Results: The data of 120 patients were analyzed,and 60 patients were in the group of levofloxacin ear drop and the other 60 in the group of ofloxacin ear drop.Efficacy assessment based on symptom score reducing index showed that the efficacy rate of levofloxacin ear drop was 96.67% and that of the ofloxacin ear drop was 85.00%;the eradication rate of pathogens in the group of levofloxacin ear drop was 96.15% and in the group of ofloxacin ear drop was 95.83%.No significant difference was showed between two groups(both P<0.05).Conclusions: Levofloxacin ear drop is effective and safe in treating otitis media.The efficacy of levofloxacin ear drop is similar to that of ofloxacin ear drop.