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| 褪黑素对子宫内膜异位症大鼠细胞因子及NK细胞活性的作用 | |
| 引用本文： | 邓云,陈惠祯,齐海英,李光仪. 褪黑素对子宫内膜异位症大鼠细胞因子及NK细胞活性的作用[J]. 实用医学杂志, 2006, 22(6): 624-626 |
| 作者姓名： | 邓云 陈惠祯 齐海英 李光仪 |
| 作者单位： | 1. 528251,广东省佛山市南海平洲医院妇产科 2. 430071,武汉大学中南医院妇产科 3. 528000,广东省佛山市第一人民医院妇产科 |
| 摘 要： | 目的:观察褪黑素对大鼠子宫内膜异位症模型细胞因子及自然杀伤(NK)细胞活性的影响。方法:采用手术移植法制备大鼠子宫内膜异位症模型,大鼠随机分为正常对照组、模型对照组和褪黑素高、低剂量组,测定大鼠的血清TNF-α、IL-6、IL-8及脾脏NK细胞活性。结果:褪黑素治疗组与模型组相比血清TNF-α、IL-6、IL-8活性明显降低,脾脏NK细胞活性显著增高。结论:褪黑素对子宫内膜异位症大鼠具有治疗作用,其作用机制可能与其抑制TNF-α、IL-6、IL-8以及增强脾脏NK细胞活性有关。 |
| 关 键 词： | 子宫内膜异位症 褪黑素 自然杀伤细胞 细胞因子类 |
| 收稿时间： | 2005-10-08 |
| 修稿时间： | 2005-10-08 |
Effects of melatonin on cytokines and nature kill cells in endometriosis rat model |
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| DENG Yun,CHEN Hui-zhen,QI Hai-ying,LI Guang-yi. Effects of melatonin on cytokines and nature kill cells in endometriosis rat model[J]. The Journal of Practical Medicine, 2006, 22(6): 624-626 | |
| Authors: | DENG Yun CHEN Hui-zhen QI Hai-ying LI Guang-yi |
| Affiliation: | Department of Obstetrics and Gynecology, Pingzhou Hospital of Foshan City, Foshan 528251, China |
| Abstract: | Objective To observe the effects of melatonin on cytokines and nature kill cells in endometriosis rat models. Methods Rats were randomly divided into four groups, including normal control group(n=10), model control group(n=10), melatonin group 1(melatonin 2 mg/kg, n=10) and 2(melatonin 4 mg/kg, n=10). The endometriosis rat models were induced by surgical implantation. At the end of the experiment, the levels of serum TNF- α , IL- 6 , IL- 8 and the activity of nature kill cells were measured. Result The leve... |
| Keywords: | Endometriosis Melatonin NK cell Cytokines |
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