131I和132I致大鼠甲状腺滤泡上皮细胞核的形态计量学改变

目的 为放射性碘危害与医学防护的研究提供资料。方法 应用图像分析技术和形态计量学方法，测量了＾１３１、＾１３２Ｉ注往后２０个月大鼠甲状腺滤泡上皮细胞核的形态计量学参数的变化。结果 各剂量组滤泡上皮细胞核截面积、等效直径增大，形态因子明显小于对照组（Ｐ〈０．０５或Ｐ〈０．０１），异形指数明显大于对照组（Ｐ〈０．０５￣Ｐ〈０．０１），体积密度，表面积密度、数密度呈先增加后减少的变化特点。结论表明细胞受

Morphometric changes in epithelial cell nuclei of rat thyroid follicles induced by 131I and 132I

Objective To study harmfulness of radioiodine and its medical protection.Method By using image analysis technique and morphometry, changes in morphometric parameters in epithelial cell nuclei of rat thyroid follicles were determined 20 months after injection of ¹³¹I and ¹³²I.Results The results showed that in various dosage groups the area and eqivalent diameter enlarged, the morphometric factor was evidently smaller than that of the control group(P<0.05 or P<0.01), and the form irregular index was significantly larger than that of the control group (P<0.05 P<0.01).The volume density, surface area density, numerical density of nuclei of follicular epithelial cells in various dose groups all showed the feature of increase at first and reduction afterwards.Conclusion It is indicated that the nuclei of epithelial cells increased and its shape became not only flat, but also anisomorphic after the cells were irradiated with radioiodine.The reason why volume density and surface area density showed increase or decrease is due to the change in numerical density of nuclei of epithelial cells.It was found by regresion analysis of the numerical density of nuclei of epithelial cells and incidence of thyroid tumor induced by radioiodine that they bear a remarkable positive correlationY=1/(3.37×10³ +5.85×10³/X₁), R1=0.8435], suggesting that the incidence of thyroid tumor is related to the number of cell per unit volume.