| ASPP2蛋白与肿瘤相关性的研究进展 |
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| 引用本文： | 何友虎,王东军. ASPP2蛋白与肿瘤相关性的研究进展[J]. 医学综述, 2009, 15(21): 3213-3216 |
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| 作者姓名： | 何友虎 王东军 |
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| 作者单位： | 广东医学院,广东,湛江,524001 |
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| 摘 要： | p53凋亡刺激蛋白(ASPP)由富含脯氨酸的结构域、SH3结构域、锚蛋白重复序列3部分组成,其家族成员ASPP2能与抑癌基因p53特异性结合,增强p53促进细胞凋亡的功能,而并不影响p53的细胞生长抑制功能,与肿瘤的发生关系密切。研究并利用ASPP2在肿瘤形成中的作用能更好地指导肿瘤治疗策略的制订。本文就近年来ASPP2蛋白与肿瘤相关性的研究进展予以综述。
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| 关 键 词： | ASPP2 p53 凋亡 肿瘤 |
Advance of ASPP2 in Tumor |
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| HE You-hu,WANG Dong-jun. Advance of ASPP2 in Tumor[J]. Medical Recapitulate, 2009, 15(21): 3213-3216 |
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| Authors: | HE You-hu WANG Dong-jun |
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| Affiliation: | HE You-hu, WANG Dong-jun. ( Guangdong Medical College, Zhanjiang 524001, China ) |
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| Abstract: | Apoptosis stimulating protein of p53 （ ASPP ） is composed by 3 parts： protline - rich domain, SH3-domain and ankyrin-repeats. ASPP2, a member of the ASPP family, is proved to interact with the tumor-suppressor p53 specifically and influence the apoptotic response of cells without affecting p53-induced cell cycle arrest. ASPP2 plays an important role in tumorigenesis. Understanding and exploiting the ASPP status in human cancers will ＇allow us to develop better strategies to treat cancer. This article reviewed the most recent inforomtion concerning the study progress of ASPP2 in human cancers. |
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| Keywords: | ASPP2 p53 |
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