CASP8AP2 is a promising prognostic indicator in pediatric acute lymphoblastic leukemia |
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| Authors: | Jiao Ying Cui Lei Gao Chao Li Weijing Zhao Xiaoxi Liu Shuguang Wu Minyuan Deng Guoren Li Zhigang |
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| Affiliation: | a Key Laboratory of Major Diseases in Children, Ministry of Education & National Key Discipline of Pediatrics, Ministry of Education & Department of Hematology, Beijing Children's Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, China
b Department of Urology, School of Medicine, University of California, San Francisco, CA, USA |
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| Abstract: | The prognostic significance of caspase 8 associated protein 2 (CASP8AP2) in pediatric ALL is controversial. We determined a cut-off of CASP8AP2 expression in bone marrow samples of 39 newly diagnosed patients, and found a significantly poor bone marrow relapse-free survival (p = 0.019) in low-expression group and verified it in another cohort of 106 patients (p = 0.002). Furthermore, as an independent prognostic factor, CASP8AP2 expression was correlated to minimal residual disease (MRD), and incorporating it with MRD would help to identify patients at greater risk of bone marrow relapse. We also developed an algorithm comprised of clinical risk and CASP8AP2 expression, which could predict bone marrow relapse more accurately. |
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| Keywords: | Pediatric leukemia Acute lymphoblastic leukemia CASP8AP2 Prognostic indicator Bone marrow relapse Minimal residual disease |
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