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Hypoglycemic effect of astaxanthin from shrimp waste in alloxan-induced diabetic mice |
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| Authors: | Juan-juan Wang Zhi-qiang Chen Wen-qing Lu |
| Affiliation: | 1. Key Laboratory of Nuclear Agriculture, Isotope Institute Co., Ltd, Henan Academy of Sciences, Zhengzhou, 450015, People’s Republic of China 2. Key Laboratory of Nutrition and Safety of Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, People’s Republic of China 3. State Key Laboratory of Animal Nutrition, China Agricultural University, No. 2. Yuanmingyuan West Road, Beijing, 100193, People’s Republic of China |
| Abstract: | Hypoglycemic effect of astaxanthin obtained from shrimp waste was assessed in alloxan-induced diabetic and normal mice. Animals received oral administration of astaxanthin in dose of 5 and 10?mg/kg. The plasma glucose levels were examined and compared with that of metformin and gliclazide. Administration of astaxanthin (5 and 10?mg/kg) produced significantly fall on plasma glucose in alloxan-induced diabetic mice, while a slight fall in normal mice. In normal mice, postprandial hyperglycemia was significantly suppressed by oral administration of astaxanthin, which significantly lowered the postprandial area under curve. These results demonstrate that astaxanthin is effective in controlling hypoglycemia in animal model of type 1 diabetes mellitus. Therefore, astaxanthin can be a useful natural oral agent to treat diabetes. |
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