Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines |
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| Authors: | Khaled A. M. Abouzid Nadia A. Khalil Eman M. Ahmed |
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| Affiliation: | 1. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt
2. Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
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| Abstract: | A series of new phthalazine derivatives 3a–i and 4a–c were synthesized via the reaction of 1-chlorophthalazine derivative 2 with either N-substituted-piperazines, primary or their secondary amines. The structure of the synthesized, new compounds were characterized by spectral data. The anti-proliferative activity on human breast cancer cell line MCF-7 of the synthesized compounds was determined. The results showed that six of the test compounds (3a, 3g, 3i, and 4a–c) displayed potent cytotoxic activity ranging from 1.4 to 2.3?μmol. |
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