聪脑汤对实验性阿尔茨海默病大鼠单胺类神经递质的影响

目的探讨聪脑汤对实验性阿尔茨海默病（AD）大鼠模型学习记忆能力的影响及作用机制。方法60只大鼠随机分为正常组、假手术组、模型组、聪脑汤大、中、小剂量组。采用D-半乳糖合并鹅膏覃氨酸损毁大脑基底核神经元的方法复制模型。各组动物以通道式水迷宫游出时间和错误次数为学习记忆评价指标，水迷宫试验结束后各组测定脑海马单胺类神经递质含量的变化。结果与正常组与假手术组相比，模型组动物水迷宫游出时间和错误次数显著升高，海马多巴胺（DA）、去甲肾上腺素（NE）、5-羟色胺（5-HT）含量水平明显下降。与模型组相比，聪脑汤大、中、小剂量组游出时间和错误次数均显著降低，同时能明显升高海马DA、NE、5-HT水平．其中以高剂量组作用更明显。结论聪脑汤能改善模型大鼠的学习记忆功能，其作用机制与提高AD模型大鼠海马DA、NE、5-HT含量有关。

Effect of Congnao Decoction on Activity of Dopaminergic Neuro-transmitter in Rat Dementia Model

Objective To observe the effect of Congnao decoction on activity of Dopaminergic Neuro-transmitter in Rat Dementia Model.Methods Sixty male SD rats were randomized into normal group, sham operation control group, model group, Congnao decoction treatment group1 (lower dosage),group 2 (medium dosage) and group 3 (high dosage). Basal forebrain-injured rat was used as model of Alzheimer's disease. Water maze was applied in six groups. The activity of dopaminergic neuro-transmitter in brain was detected.Results Compared with normal group and sham operation control group, the swimming time and the error number were obviously prolonged and the level of dopaminergic neuro-transmitter in brain was decreased significantly in model group. The swimming time and error number were shortened, the levels of dopaminergic neuro-transmitter in brain were increased in three treatment groups compared with model group. Conclusion Congnao decoction could improve the ability of learning and memory, increase cerebral dopaminergic neuro-transmitter in brain of model rat, exerting a positive effect on treatment of cognitive dysfunction.