| 血液系统肿瘤中的人类错配修复系统 |
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| 引用本文： | 吴裕丹. 血液系统肿瘤中的人类错配修复系统[J]. 中国实验血液学杂志, 2001, 9(1): 75-79 |
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| 作者姓名： | 吴裕丹 |
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| 作者单位： | 同济医科大学附属协和医院血液病研究所,武汉430022 |
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| 摘 要： | 人类错配修复（mismatch repair,MMR)系统由MutH,MutL和MutS三大家族的蛋白组成。它们修正核苷酸摄取错误、增强DNA复制忠实性、降低基因的自发突变率、维持着微卫星位点乃至整个基因组的稳定。MMR系统功能低下就有可能导致癌变发生,本就错配修复系统与血液系统肿瘤的相关性作一概述。
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| 关 键 词： | 人类错配修复系统 血液系统肿瘤 核苷酸 |
| 修稿时间： | 2000-06-25 |
Human Mismatch Repair System in Hematologic Malignancies |
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| WU Yu-Dan. Human Mismatch Repair System in Hematologic Malignancies[J]. Journal of experimental hematology, 2001, 9(1): 75-79 |
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| Authors: | WU Yu-Dan |
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| Abstract: | The human mismatch repair (hMMR) system consists of members of three super-families, namely MutH, MutL and MutS. They are able to correct the error of nucleotide incorporation, increase the fidelity of DNA replication, reduce spontaneous mutation, and maintain the stability of microsatellite loci and genome. The dysfunction of MMR may induce to carcinogenesis. The relation of MMR and hematologic malignancies is presented in the article. |
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| Keywords: | human mismatch repair system hematologic malignancy |
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