| 雷公藤化学成分的研究 Ⅲ.两种新二萜内酯——雷酚内酯甲醚和雷酚新内酯的分离及结构 |
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| 引用本文： | 邓福孝,周炳南,宋国强,胡昌奇. 雷公藤化学成分的研究 Ⅲ.两种新二萜内酯——雷酚内酯甲醚和雷酚新内酯的分离及结构[J]. 药学学报, 1982, 17(2): 146-150 |
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| 作者姓名： | 邓福孝 周炳南 宋国强 胡昌奇 |
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| 作者单位： | 福建省医药研究所，中国科学院上海药物研究所，中国科学院上海药物研究所，上海第一医学院药学系 福州 |
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| 摘 要： | 从福建产雷公藤(Tripterygium wilfordii Hook.f.)的根皮中分离到三种二萜内酯。(1)雷酚内酯(triptophenolide),C20H24O3,熔点232～233℃。(2)雷酚内酯甲醚(triptophenolide methyl ether),C21H26O3,熔点152～154℃。(3)雷酚新内酯(neotriptophenolide),C21H26O4,熔点189～191℃。根据理化性质及UV、IR、1HNMR、13CNMR、MS等光谱数据,推测化学结构分别为Ⅴ、Ⅵ及Ⅶ。Ⅵ与Ⅶ是二种新的二萜内酯化合物。
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| 关 键 词： | 雷公藤 二萜内酯 雷酚内酯 雷酚内酯甲醚 雷酚新内酯 |
| 收稿时间： | 1981-02-09 |
STUDIES ON THE CHEMICAL CONSTITUENTS OF TRIPTERYGIUM WILFORDII HOOK.F. Ⅲ. THE ISOLATION AND STRUCTURE OF TWO NEW DITERPENOID-LACTONES, TRIPTOPHENOLIDE METHYL ETHER AND NEOTRIPTOPHENOLIDE |
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| DENG Fu-xiao. STUDIES ON THE CHEMICAL CONSTITUENTS OF TRIPTERYGIUM WILFORDII HOOK.F. Ⅲ. THE ISOLATION AND STRUCTURE OF TWO NEW DITERPENOID-LACTONES, TRIPTOPHENOLIDE METHYL ETHER AND NEOTRIPTOPHENOLIDE[J]. Acta pharmaceutica Sinica, 1982, 17(2): 146-150 |
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| Authors: | DENG Fu-xiao |
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| Abstract: | In a previous paper (1) the isolation of triptolide, tripdiolide and triptonolide from Tripterygium wilfordii Hook. f. was reported. This paper reports the isolation of three other diterpenoid-lactones: (1) triptophenolide, C20H24O3, mp 232～233℃; (2) triptophenolide methyl ether, C21H26O3, mp 152～154℃, and (3) neotriptophenolide, C21H26O4, mp 189～191℃. Their structures are assigned as Ⅴ, Ⅵ and Ⅶ, respectively, by spectroscopic analysis (UV, IR, MS, 1HNMR and 13CNMR) and preparation of their derivatives. It has beert shown that Ⅵ and Ⅶ are new diterpenoid compounds. |
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| Keywords: | Tripterygium wilfordii Diterpenoid-lactone Triptophenolide Triptophenolide methyl ether Neotriptophenolide. |
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