| 胰高血糖素样肽-1及其类似物保护认知功能的研究进展 |
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| 引用本文： | 张亮,闵苏.胰高血糖素样肽-1及其类似物保护认知功能的研究进展[J].国际麻醉学与复苏杂志,2014,35(7):660-663. |
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| 作者姓名： | 张亮 闵苏 |
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| 作者单位： | 张亮 (重庆医科大学附属第一医院麻醉科,400016)； 闵苏 (重庆医科大学附属第一医院麻醉科,400016)； |
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| 基金项目： | 卫生部国家临床重点专科建设基金资助项目(项目编号：财社(2011)170号)重庆市医学重点学科计划项目(项目编号：渝卫科教(2007)2号) |
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| 摘 要： | 背景 认知功能障碍是指学习记忆、思维判断等大脑高级功能异常,目前尚无确切的防治药物.2型糖尿病被公认为发生认知功能障碍的危险因素.胰高血糖素样肽-1（glucagon-like peptide-1,GLP-1）及其类似物是一种针对2型糖尿病的新型降糖药,研究发现其还具有保护认知功能的作用. 目的 为GLP-1及其类似物应用于临床防治认知功能障碍提供理论依据. 内容 就GLP-1及其类似物的保护认知功能的研究现状作一综述. 趋向 有望成为防治认知功能障碍等神经病理性疾病的新型药物.
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| 关 键 词： | 类似物 认知功能 胰高血糖素样肽-1 |
Protective effects of glucagon-like peptide-1 and its analogs on cognitive function |
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| Zhang Liang,Min Su.Protective effects of glucagon-like peptide-1 and its analogs on cognitive function[J].international journal of anesthesiology and resuscitation,2014,35(7):660-663. |
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| Authors: | Zhang Liang Min Su |
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| Institution: | ( Department of Anesthesiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China) |
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| Abstract: | Background Cognitive dysfunction is defined as mental health disorder that affect learning,memory,thinking,judgment and other higher brain function.However,there are no definitive drugs to prevent the cognitive dysfunction.Type 2 diabetes mellitus is recognized as one risk factor for cognitive dysfunction.Glucagon-like peptide-1 （GLP-1） and its analogues,a class of antidiabetic agents,have the protective effects on cognitive function.Objective To provide the theoretical basis for the prevention and treatment of GLP-1 and its analogues on cognitive dysfunction.Content This review will focus on protective effects of GLP-1 and its analogs on cognitive function.Trend GLP-1 and its analogs are expected to become new drugs for prevention and treatment of neuropathic diseases such as cognitive dysfunction. |
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| Keywords: | Analogue Cognitive function Glucagon-like peptide-1 |
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