间充质干细胞-支架复合体修复膝关节半月板损伤

背景：半月板损伤常规治疗手段效果并不显著，随着组织工程学的进展，间充质干细胞-支架复合体有望应用于此方面的治疗。 目的：对间充质干细胞-支架技术治疗半月板损伤的相关研究进行综述，为后续研究和临床应用提供参考。 方法：第一、二作者共同检索PubMed、中国期刊全文数据库（CNKI）、维普数据库和万方数据库1980至2013年有关间充质干细胞-支架复合体修复半月板损伤的文献，英文检索词为“mesenchymal stem cel ，meniscus injury，tissue engineering，scaffold，stent”，中文检索词为“间充质干细胞，半月板损伤，组织工程”。同一领域文献选择近期发表或发表在权威杂志的文章，排除Meta分析及重复性研究。共检索到文献282篇，根据纳入标准选取59篇文献进行综述。 结果与结论：目前很多研究表明间充质干细胞可在体外或体内被诱导分化为软骨细胞，间充质-支架复合体对半月板损伤有明显疗效。虽然此技术仍处于探索阶段，但其具有取材方便，无抗原性，有生命力等优点，在治疗半月板损伤方面有着广阔的应用前景。

Mesenchymal stem cells-stents complex in repair of meniscus injury in knee joint

BACKGROUND：Meniscus injury is a common disease, whose curative effect is not obvious. The clinical application of tissue engineering technology is gradual y rising, and mesenchymal stem cells-stents complex is expected to be used for the treatment of meniscus injury. OBJECTIVE：To review the application process of mesenchymal stem cells-stents complex in meniscus injury, in order to provide reference for further study and clinical practice. METHODS：A computer-based online search of PubMed database, VIP database, Wanfang database and China National Knowledge Infrastructure between 1980 and 2013 was performed to search related articles on mesenchymal stem cells-stents complex in meniscus injury. The key words were“mesenchymal stem cell, meniscus injury, tissue engineering, scaffold, stent”in English and“mesenchymal stem cell, meniscus injury, tissue engineering”in Chinese. For the articles in the same field, we preferred the ones published recently or in authorize journals. Meta-analysis and repetitive studies were excluded. 282 articles were included, and final y 59 articles were included according to inclusion criteria. RESULTS AND CONCLUSION：Nowadays, numerous experiments showed that mesenchymal stem cells could differentiate into chondrocytes both in vivo or vitro. Mesenchymal stem cells-stents complex could be effective to meniscus injury. Although this technique is stil in exploratory stage, it has promising application prospects in＆nbsp;treatment of meniscus injury, because it is characterized by convenience to col ect samples, vitality and no antigenicity.