脐血干细胞移植与神经生长因子联合治疗小儿脑性瘫痪的安全性分析

背景：脐血干细胞移植联合神经生长因子治疗小儿脑性瘫痪是临床研究热点。目的：分析脐血干细胞移植联合神经生长因子治疗小儿脑性瘫痪疗效及安全性。方法：选取天津红桥医院儿科2011年11月至2013年2月收治的脑性瘫痪患儿80例，按治疗方法分别分为试验组（n=40）和对照组（n=40），分别接受脐血干细胞移植与神经生长因子联合治疗和单独神经生长因子治疗。结果与结论：与治疗前相比，2组患儿治疗后脑性瘫痪综合功能评定表及粗大运动功能测量量表分值均有所提高（P＜0.05），且白细胞计数、中性粒细胞分数、总胆红素、丙氨酸氨基转移酶、天冬氨酸氨基转移酶明显升高（P ＜0.05），且试验组患儿的治疗效果优于对照组（P ＜0.05）。所有患儿未见严重不良反应。说明脐血干细胞移植联合神经生长因子治疗小儿重症脑性瘫痪疗效显著，安全性高。

Safety analysis of umbilical cord blood stem cell transplantation combined with nerve growth factor in the treatment of cerebral palsy in children

BACKGROUND：Umbilical cord blood stem celltransplantation combined with nerve growth factor in the treatment of children with cerebral palsy is a clinical hotspot. OBJECTIVE：To analyze the efficacy and safety of umbilical cord blood stem celltransplantation combined with nerve growth factor in the treatment of cerebral palsy in children. METHODS：A total of 80 children with cerebral palsy admitted at the Department of Pediatrics, Hongqiao Hospital of Tianjin, China from 2011 November to 2013 February were enrol ed, and according to therapeutic methods, they were divided into experimental group （n=40;treated with umbilical cord blood stem celltransplantation combined with nerve growth factor） and control group （n=40;treated with nerve growth factor alone）. RESULTS AND CONCLUSION：After treatment, scores on comprehensive function assessment scale and gross motor function measure scale were significantly increased in the two groups （P〈0.05）, while white cellcount, neutrophil fraction, and levels of total bilirubin, alanine aminotransferase and aspartate aminotransferase were also increased （P〈0.05）. Moreover, the experimental group showed a better outcome than the control group after treatment （P〈0.05）. Al of the patients had no serious adverse reactions. Umbilical cord blood stem celltransplantation combined with nerve growth factor has dramatic curative effects in children with severe cerebral palsy significant curative effect, with high safety.